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- W2398720172 abstract "Graft-versus-host disease (GVHD) is a major complication associated with morbidity and mortality following allogeneic hematopoietic stem cell transplantation (HSCT). GVHD can be fatal, as patients frequently fail to respond to conventional immunosuppressants and no established second-line therapy is available. Stem cells have emerged as a therapeutic approach in a range of medical fields, including regenerative medicine, cancer, autoimmune diseases, and inflammatory diseases, because of their unique properties. In particular, mesenchymal stem cells (MSCs) have created increasing interest as a therapeutic agent for various immune-mediated diseases including GVHD. MSCs demonstrate therapeutic potential by exerting potent immunosuppressive effects through interactions between lymphocytes associated with both the innate and adaptive immune system. Preclinical experiments using MSCs for the treatment of GVHD have provided critical insights into the mechanism of action of MSCs and evidence for clinical translation. In the clinical setting, Ringden’s pilot study using MSCs to treat a steroid-refractory GVHD pediatric patient was a milestone in the field of MSC therapy, which leads to numerous worldwide studies on steroid-refractory GVHD, de novo GVHD, chronic GVHD treatment, and GVHD prevention. In this chapter, we focus on the recent advances of MSCs for the treatment of GVHD in both preclinical and clinical settings. We discuss the current limitations and highlight the future considerations that should be made when using stem cell therapy for GVHD." @default.
- W2398720172 created "2016-06-24" @default.
- W2398720172 creator A5059291757 @default.
- W2398720172 creator A5063293563 @default.
- W2398720172 date "2015-01-01" @default.
- W2398720172 modified "2023-09-25" @default.
- W2398720172 title "Stem Cell Therapy for GVHD" @default.
- W2398720172 cites W1597188925 @default.
- W2398720172 cites W1883799289 @default.
- W2398720172 cites W1977121422 @default.
- W2398720172 cites W1981994822 @default.
- W2398720172 cites W1982023994 @default.
- W2398720172 cites W1982408656 @default.
- W2398720172 cites W1982916645 @default.
- W2398720172 cites W1983493560 @default.
- W2398720172 cites W1984515197 @default.
- W2398720172 cites W1988857766 @default.
- W2398720172 cites W1989632074 @default.
- W2398720172 cites W1991460349 @default.
- W2398720172 cites W1999360673 @default.
- W2398720172 cites W2004995152 @default.
- W2398720172 cites W2005943573 @default.
- W2398720172 cites W2007536176 @default.
- W2398720172 cites W2008323089 @default.
- W2398720172 cites W2009626854 @default.
- W2398720172 cites W2011137808 @default.
- W2398720172 cites W2011653132 @default.
- W2398720172 cites W2012073875 @default.
- W2398720172 cites W2013758266 @default.
- W2398720172 cites W2014482299 @default.
- W2398720172 cites W2015862367 @default.
- W2398720172 cites W2016249583 @default.
- W2398720172 cites W2016695470 @default.
- W2398720172 cites W2016707632 @default.
- W2398720172 cites W2019495971 @default.
- W2398720172 cites W2024088021 @default.
- W2398720172 cites W2024326908 @default.
- W2398720172 cites W2024971445 @default.
- W2398720172 cites W2025050313 @default.
- W2398720172 cites W2025294489 @default.
- W2398720172 cites W2025371271 @default.
- W2398720172 cites W2028239901 @default.
- W2398720172 cites W2028702444 @default.
- W2398720172 cites W2029544795 @default.
- W2398720172 cites W2029959553 @default.
- W2398720172 cites W2030480905 @default.
- W2398720172 cites W2030583421 @default.
- W2398720172 cites W2030653181 @default.
- W2398720172 cites W2033230449 @default.
- W2398720172 cites W2033284503 @default.
- W2398720172 cites W2034430001 @default.
- W2398720172 cites W2035065708 @default.
- W2398720172 cites W2036736974 @default.
- W2398720172 cites W2038270895 @default.
- W2398720172 cites W2044869938 @default.
- W2398720172 cites W2045080708 @default.
- W2398720172 cites W2045254759 @default.
- W2398720172 cites W2047003816 @default.
- W2398720172 cites W2049430343 @default.
- W2398720172 cites W2052004719 @default.
- W2398720172 cites W2053911973 @default.
- W2398720172 cites W2054274983 @default.
- W2398720172 cites W2055670245 @default.
- W2398720172 cites W2056315364 @default.
- W2398720172 cites W2057887260 @default.
- W2398720172 cites W2058102240 @default.
- W2398720172 cites W2058473775 @default.
- W2398720172 cites W2059378220 @default.
- W2398720172 cites W2060640813 @default.
- W2398720172 cites W2062134795 @default.
- W2398720172 cites W2063574893 @default.
- W2398720172 cites W2063764243 @default.
- W2398720172 cites W2064919073 @default.
- W2398720172 cites W2067689577 @default.
- W2398720172 cites W2069399162 @default.
- W2398720172 cites W2072308381 @default.
- W2398720172 cites W2073024911 @default.
- W2398720172 cites W2073045132 @default.
- W2398720172 cites W2074188863 @default.
- W2398720172 cites W2076012577 @default.
- W2398720172 cites W2076568423 @default.
- W2398720172 cites W2078502470 @default.
- W2398720172 cites W2080538689 @default.
- W2398720172 cites W2081461736 @default.
- W2398720172 cites W2081867547 @default.
- W2398720172 cites W2085216114 @default.
- W2398720172 cites W2085704445 @default.
- W2398720172 cites W2087353148 @default.
- W2398720172 cites W2089719302 @default.
- W2398720172 cites W2089971263 @default.
- W2398720172 cites W2092929403 @default.
- W2398720172 cites W2093513978 @default.
- W2398720172 cites W2094202626 @default.
- W2398720172 cites W2095056467 @default.
- W2398720172 cites W2100764718 @default.
- W2398720172 cites W2101937238 @default.
- W2398720172 cites W2103110468 @default.
- W2398720172 cites W2106072740 @default.