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• W2398720259 abstract "Objective The aim of this study was to investigate the susceptibility and prognostic implications of the cyclin D1 gene（ CCND1 ） G870A polymorphism to nasopharyngeal carcinomas （NPC） in Han population in Yunnan China. Methods Two hundred and forty one cases with NPC and 271 matched cancer-free controls were genotyped for the CCND1 G870A polymorphism by polymerase chain reaction- restriction fragment length polymorphism（PCR-RFLP） and sequencing. The adjusted odds ratios （OR） and 95% confidence intervals （CI） were calculated by using unconditional logistic regression model. Overall survival was assessed using univariate and multivariate analyses. Results Contrast with homozygous CCND1 G870G, A allele significantly increasing risk of NPC was associated with homozygous A870A （ OR = 4. 79, 95% CI 2.77-8.28, P<0. 001） and heterozygous A870G （OR = 1.72, 95% CI 1.10-2.68,P= 0. 017）. The subjects at least having one CCND1 870A allele had OR of 2. 40（95% CI 1.59 - 3.63, P < 0. 001 ）. Furthermore, smoking may increase the risk of developing NPC interacting with CCND1 C-870A polymorphism. Kaplan-Meier analysis and Cox regression analysis demonstrated that the five-year survival rate of subjects with AA, AG and GG genotype was 56. 2% , 78.5% and 81.4% （ AA vs GG, P =0. 003 ; AA vs AG, P = 0. 012; AG vs GG, P = 0. 132）, but not independent prognostic factor in NPC （P = 0. 501）. Condusions The CCND1 870A allele is associated with the NPC in Han population in Yunnan China, meanwhile, showed a significant prognosis for those patients.Key words: Nasopharyngeal neoplasms; Carcinoma, squamous cell; Genes, bcl-1; Polymorphism, single nucleotide; Genetic predisposition to disease; Prognosis" @default.
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• W2398720259 date "2009-03-01" @default.
• W2398720259 modified "2023-09-22" @default.
• W2398720259 title "Cyclin D1 gene G870A polymorphism and susceptibility to nasopharyngeal carcinoma" @default.
• W2398720259 doi "https://doi.org/10.3760/cma.j.issn.1673-0860.2009.03.011" @default.
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