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• W2398752419 startingPage "8143" @default.
• W2398752419 abstract "The objective of this study was to investigate the transepithelial transport of RVPSL (Arg-Val-Pro-Ser-Leu), an egg-white-derived peptide with angiotensin I-converting enzyme (ACE) inhibitory and antihypertensive activity, in human intestinal Caco-2 cell monolayers. Results revealed that RVPSL could be passively transported across Caco-2 cell monolayers. However, during the process of transport, 36.31% ± 1.22% of the initial RVPSL added to the apical side was degraded, but this degradation decreased to 23.49% ± 0.68% when the Caco-2 cell monolayers were preincubated with diprotin A (P < 0.001), suggesting that RVPSL had a low resistance to various brush border membrane peptidases. When transport from the apical side to the basolateral side was investigated, the apparent permeability coefficient (Papp) was (6.97 ± 1.11) × 10(-6) cm/s. The transport route of RVPSL appears to be the paracellular pathway via tight junctions, as only cytochalasin D, a disruptor of tight junctions (TJs), significantly increased the transport rate (P < 0.001). In addition, the relationship between the structure of RVPSL and transport across Caco-2 cell monolayers was studied by mutation of RVPSL. It was found that N-terminal Pro residues were more beneficial for transport of pentapeptides across Caco-2 cell monolayers than Arg and Val. Furthermore, RVPSL could be more easily transported as smaller peptides, especially in the form of dipeptides and tripeptides." @default.
• W2398752419 created "2016-06-24" @default.
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• W2398752419 date "2015-09-10" @default.
• W2398752419 modified "2023-10-16" @default.
• W2398752419 title "Transport of Antihypertensive Peptide RVPSL, Ovotransferrin 328–332, in Human Intestinal Caco-2 Cell Monolayers" @default.
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• W2398752419 doi "https://doi.org/10.1021/acs.jafc.5b01824" @default.
• W2398752419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26335384" @default.
• W2398752419 hasPublicationYear "2015" @default.
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