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- W2398813713 abstract "Signaling downstream of chemokine and other chemoattractant receptors regulates the localization, positioning, and homeostatic trafficking of leukocytes as well as the recruitment and localization of leukocytes at inflammatory sites. Ligand-induced changes in the molecular conformation of chemoattractant receptors trigger the engagement of heterotrimeric G proteins promoting α subunit GTP/GDP exchange. This functionally releases βγ subunits from the heterotrimer, which activate the downstream effectors needed to initiate leukocyte polarization, gradient sensing, and directional migration. Numerous regulatory mechanism targeting both the receptors and heterotrimeric G proteins help coordinate these signaling pathways. Failures in these regulatory pathways can severely impair chemokine receptor signaling and lead to pathology." @default.
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- W2398813713 date "2016-01-01" @default.
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- W2398813713 title "Chemokine Receptor Signaling" @default.
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- W2398813713 doi "https://doi.org/10.1016/b978-0-12-374279-7.11014-8" @default.
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