Matches in SemOpenAlex for { <https://semopenalex.org/work/W2398825239> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- W2398825239 endingPage "91" @default.
- W2398825239 startingPage "285" @default.
- W2398825239 abstract "The hypothesis is proposed that regulation of hemopoiesis is largely accomplished by expansion or contraction of the committed stem cell compartments and that pluripotential stem cells are normally not involved or in cycle. The thesis appears supported by the fact that erythropoietin affects the committed red cell precursors, that 98% of marrow mitoses have been shown to occur in cells clearly recognizable as red or white cell precursors (while the pluripotential stem cells by definition are not so recognizable), and that it has been shown (by the spleen nodule assay) that the pluripotential stem cell compartment in the marrow cannot be readily expanded. The major objection to the proposed hypothesis are tritiated thymidine suicide data, which suggest that up to 20% of pluripotential stem cells may be constantly in cycle in some stains of mice. Preliminary experimental evidence supporting the hypothesis has been obtained: normal pluripotential stem cells which transfused into normal isologous mice are not lost as has been assumed but proliferate after irradiation, suggesting that it takes a special stimulus to turn-on the normally quiescent pluripotential stem cells." @default.
- W2398825239 created "2016-06-24" @default.
- W2398825239 creator A5090731323 @default.
- W2398825239 date "1977-01-01" @default.
- W2398825239 modified "2023-09-23" @default.
- W2398825239 title "Pluripotential and committed hemopoietic stem cells. A hypothesis." @default.
- W2398825239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/335355" @default.
- W2398825239 hasPublicationYear "1977" @default.
- W2398825239 type Work @default.
- W2398825239 sameAs 2398825239 @default.
- W2398825239 citedByCount "0" @default.
- W2398825239 crossrefType "journal-article" @default.
- W2398825239 hasAuthorship W2398825239A5090731323 @default.
- W2398825239 hasConcept C109159458 @default.
- W2398825239 hasConcept C203014093 @default.
- W2398825239 hasConcept C28328180 @default.
- W2398825239 hasConcept C86803240 @default.
- W2398825239 hasConcept C95444343 @default.
- W2398825239 hasConceptScore W2398825239C109159458 @default.
- W2398825239 hasConceptScore W2398825239C203014093 @default.
- W2398825239 hasConceptScore W2398825239C28328180 @default.
- W2398825239 hasConceptScore W2398825239C86803240 @default.
- W2398825239 hasConceptScore W2398825239C95444343 @default.
- W2398825239 hasIssue "2" @default.
- W2398825239 hasLocation W23988252391 @default.
- W2398825239 hasOpenAccess W2398825239 @default.
- W2398825239 hasPrimaryLocation W23988252391 @default.
- W2398825239 hasRelatedWork W1978598034 @default.
- W2398825239 hasRelatedWork W1996916774 @default.
- W2398825239 hasRelatedWork W2038751426 @default.
- W2398825239 hasRelatedWork W2081953211 @default.
- W2398825239 hasRelatedWork W2120223845 @default.
- W2398825239 hasRelatedWork W2253242983 @default.
- W2398825239 hasRelatedWork W2314522894 @default.
- W2398825239 hasRelatedWork W2412102303 @default.
- W2398825239 hasRelatedWork W2414374203 @default.
- W2398825239 hasRelatedWork W325523310 @default.
- W2398825239 hasVolume "18" @default.
- W2398825239 isParatext "false" @default.
- W2398825239 isRetracted "false" @default.
- W2398825239 magId "2398825239" @default.
- W2398825239 workType "article" @default.