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• W2398913312 abstract "Neuroblastoma (NB) is the deadliest pediatric solid tumor due to its pleomorphic molecular characteristics. In the innate immune system, toll-like receptor 3 (TLR3) recognizes viral double-stranded RNAs to initiate immune signaling. Positive TLR3 expression indicates a favorable prognosis in NB patients, and is associated with MYCN-non-amplified. However, TLR3-mediated innate immune responses remain elusive in NB. In this study, we attempted to dissect the molecular mechanism underlying TLR3-agonist polyinosinic-polycytidylic acid [poly(I:C)] treatment in NB in vivo. We established NB xenograft models in non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice with MYCN-amplified SK-N-DZ (DZ) cells or MYCN-non-amplified SK-N-AS (AS) cells. Poly(I:C) treatment led to significant tumor regression in AS xenografts, but not in DZ xenografts. Through immunohistochemical analysis, significant suppression of tumor proliferation, downregulation of c-Myc expression, and upregulation of TLR3 expression were found in the treatment group. Poly(I:C) inducing activation of TLR3/IRF3-mediated innate immunity associated with downregulation of c-Myc can be found in MYCN-non-amplified SK-N-AS cells, but not in MYCN-amplified BE(2)-M17 cells. Knockdown of TLR3 disturbed poly(I:C)-induced suppression of c-Myc and upregulation of p-IRF3 in AS cells. Furthermore, poly(I:C) treatment upregulated active NF-κB, mitochondrial antioxidant manganese superoxide dismutase and 8-hydroxydeoxyguanosine, which works with reactive oxygen species (ROS) generation and DNA damage. Upregulation of active caspase 3 and cleaved poly [ADP-ribose] polymerase 1 were found in poly(I:C)-treated AS xenografts, which indicates the induction of apoptosis. Thus, our results suggest that c-Myc overexpression may increase sensitivity to poly(I:C)-induced tumor growth arrest and ROS-mediated apoptosis in NB. This study demonstrates that c-Myc protein expression has an important role in TLR3-induced innate immune responses, providing future treatment recommendations." @default.
• W2398913312 created "2016-06-24" @default.
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• W2398913312 date "2016-07-01" @default.
• W2398913312 modified "2023-10-18" @default.
• W2398913312 title "Downregulation of c-Myc is involved in TLR3-mediated tumor death of neuroblastoma xenografts" @default.
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• W2398913312 cites W1909200755 @default.
• W2398913312 cites W1932581239 @default.
• W2398913312 cites W1967139222 @default.
• W2398913312 cites W1969342260 @default.
• W2398913312 cites W1974784117 @default.
• W2398913312 cites W1975197349 @default.
• W2398913312 cites W1977145526 @default.
• W2398913312 cites W1990583562 @default.
• W2398913312 cites W1990846930 @default.
• W2398913312 cites W1996180957 @default.
• W2398913312 cites W2002301799 @default.
• W2398913312 cites W2004035680 @default.
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• W2398913312 cites W2010597170 @default.
• W2398913312 cites W2012654383 @default.
• W2398913312 cites W2014636185 @default.
• W2398913312 cites W2015415445 @default.
• W2398913312 cites W2016855149 @default.
• W2398913312 cites W2021536610 @default.
• W2398913312 cites W2022142157 @default.
• W2398913312 cites W2024149236 @default.
• W2398913312 cites W2024592805 @default.
• W2398913312 cites W2027954222 @default.
• W2398913312 cites W2028859420 @default.
• W2398913312 cites W2049370092 @default.
• W2398913312 cites W2053517103 @default.
• W2398913312 cites W2061206746 @default.
• W2398913312 cites W2067606868 @default.
• W2398913312 cites W2074688366 @default.
• W2398913312 cites W2076361525 @default.
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• W2398913312 cites W2103112751 @default.
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• W2398913312 cites W2107060734 @default.
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• W2398913312 doi "https://doi.org/10.1038/labinvest.2016.57" @default.
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