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- W2398917274 abstract "Objective To explore the correlation between the promote effects of ALC1 on the proliferation of liver cancer cells and MAPK Pathway activity.Methods The expression of ALC1 mRNA expression were detected with q RT-PCR in hepatocellular carcinoma cell line. The the colony formation and MTS experiment were applied to test the effects of proliferation after ALC1 RNA interference and Western blot was uesd to detected the phosphorylation of MEK and ERK. Results ALC1 were expressed in Huh7,HepG2 and BEL-7402 cells. The higher expression level of ALC1 was found in Huh7 cells when compared with that of HepG2 and BEL-7402 cells. The results of MTS experiment showed that the multiplication rate of Huh7 cell were significantly decreased than the of control group after treating with ALC1 siRNA(P<0.05),the colony formation rate of Huh7 cells also decreased significantly following siRNA treatment(P<0.05). Western blot results showed that the total MEK and ERK protein levels were not changed obviously after ALC1 siRNA treatment,but the p-MEK and p-ERK protein levels were remarkably decreased(P<0.05)following the expression of ALC1 was restrained. Conclusion The high expression level of ALC1 was significantly found in Huh7 cells.ALC1 promote the proliferation of hepatocellular carcinoma cells by activating the MAPK Pathway." @default.
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- W2398917274 date "2016-01-01" @default.
- W2398917274 modified "2023-09-27" @default.
- W2398917274 title "ALC1 promote the proliferation of hepatocellular carcinoma cells via the activating of MAPK pathway" @default.
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