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- W2398959900 abstract "OBJECTIVE To investigate the effects of N-methyl-D-aspartate (NMDA) receptor antagonists on restraint-induced release of prolactin (PRL) in male Wistar rats of different ages. DESIGN Rats were implanted with a brain ventricular for icv injection, and with a jugular vein cannula for iv injection. Competitive NMDA receptor antagonist AP-5 and noncompetitive NMDA receptor blocker MK-801 was injected via brain cannula or vein cannula and was restrained for 3 hours. The blood sample was collected through vein cannula during the restraint. The plasma concentration of prolactin was measured by RIA. RESULTS The restraint-induced PRL release in the adult rat (12-weeks) was significantly suppressed by MK-801 (50 microg/rat, icv; or 5 mg/kg, iv) and was partially inhibited by pretreatment of AP-5 (50, 100 microg/rat, icv), but was not changed by systemic administration of AP-5 (10 mg/kg, iv). MK-801 (5 mg/kg, iv) prevented the restraint-induced PRL release in the peripuberal rat (45-days) and in the middle-aged rat (16-months). CONCLUSION Central NMDA receptors mediate restraint-induced PRL release in the male rat." @default.
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- W2398959900 date "2003-12-01" @default.
- W2398959900 modified "2023-09-23" @default.
- W2398959900 title "NMDA receptor antagonists reduce restraint-induced release of prolactin in male rats." @default.
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