Matches in SemOpenAlex for { <https://semopenalex.org/work/W2398983973> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2398983973 endingPage "852" @default.
- W2398983973 startingPage "851" @default.
- W2398983973 abstract "The anticarcinogenic activity of hydroxytyrosyl ethyl ether (HTy-Et) compared to its precursor hydroxytyrosol (HTy) has been studied in human Caco-2 colon adenocarcinoma cells. 451 and 977 genes were differentially expressed in Caco-2 cells exposed to HTy or HTy-Et for 24 h, respectively, compared with untreated cells (P < 0.005; FDR = 0), using Affymetrix microarrays. Results showed that both HTy and HTy-Et inhibited cell proliferation and arrested the cell cycle by up-regulating p21 and CCNG2 and down-regulating CCNB1 protein expression. HTy and HTy-Et also altered the transcription of specific genes involved in apoptosis, as suggested by the up-regulation of BNIP3, BNIP3L, PDCD4 and ATF3 and the activation of caspase-3. Moreover, these polyphenols up-regulated xenobiotic metabolizing enzymes UGT1A10 and CYP1A1, enhancing carcinogen detoxification. In conclusion, these results highlight that HTy and its derivative HTy-Et modulate molecular mechanisms involved in colon cancer, with HTy-Et being more effective than HTy." @default.
- W2398983973 created "2016-06-24" @default.
- W2398983973 creator A5062219454 @default.
- W2398983973 creator A5075671587 @default.
- W2398983973 date "2012-09-01" @default.
- W2398983973 modified "2023-10-14" @default.
- W2398983973 title "L’hospitalisation : l’occasion à ne pas manquer pour traiter l’addiction au tabac" @default.
- W2398983973 cites W1548522572 @default.
- W2398983973 cites W1821872278 @default.
- W2398983973 cites W1976145789 @default.
- W2398983973 cites W2032692684 @default.
- W2398983973 cites W2048292541 @default.
- W2398983973 cites W2057773936 @default.
- W2398983973 cites W2089292144 @default.
- W2398983973 cites W2139460523 @default.
- W2398983973 cites W2412128661 @default.
- W2398983973 cites W2417665133 @default.
- W2398983973 cites W2307776645 @default.
- W2398983973 doi "https://doi.org/10.1016/j.rmr.2012.07.002" @default.
- W2398983973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22980543" @default.
- W2398983973 hasPublicationYear "2012" @default.
- W2398983973 type Work @default.
- W2398983973 sameAs 2398983973 @default.
- W2398983973 citedByCount "2" @default.
- W2398983973 countsByYear W23989839732014 @default.
- W2398983973 crossrefType "journal-article" @default.
- W2398983973 hasAuthorship W2398983973A5062219454 @default.
- W2398983973 hasAuthorship W2398983973A5075671587 @default.
- W2398983973 hasConcept C104317684 @default.
- W2398983973 hasConcept C150194340 @default.
- W2398983973 hasConcept C190283241 @default.
- W2398983973 hasConcept C502942594 @default.
- W2398983973 hasConcept C54355233 @default.
- W2398983973 hasConcept C62112901 @default.
- W2398983973 hasConcept C81885089 @default.
- W2398983973 hasConcept C86803240 @default.
- W2398983973 hasConceptScore W2398983973C104317684 @default.
- W2398983973 hasConceptScore W2398983973C150194340 @default.
- W2398983973 hasConceptScore W2398983973C190283241 @default.
- W2398983973 hasConceptScore W2398983973C502942594 @default.
- W2398983973 hasConceptScore W2398983973C54355233 @default.
- W2398983973 hasConceptScore W2398983973C62112901 @default.
- W2398983973 hasConceptScore W2398983973C81885089 @default.
- W2398983973 hasConceptScore W2398983973C86803240 @default.
- W2398983973 hasIssue "7" @default.
- W2398983973 hasLocation W23989839731 @default.
- W2398983973 hasLocation W23989839732 @default.
- W2398983973 hasOpenAccess W2398983973 @default.
- W2398983973 hasPrimaryLocation W23989839731 @default.
- W2398983973 hasRelatedWork W2009966535 @default.
- W2398983973 hasRelatedWork W2049264678 @default.
- W2398983973 hasRelatedWork W2070291783 @default.
- W2398983973 hasRelatedWork W2147761319 @default.
- W2398983973 hasRelatedWork W2355259601 @default.
- W2398983973 hasRelatedWork W2361879574 @default.
- W2398983973 hasRelatedWork W2374945858 @default.
- W2398983973 hasRelatedWork W2403499974 @default.
- W2398983973 hasRelatedWork W2745882536 @default.
- W2398983973 hasRelatedWork W3183408539 @default.
- W2398983973 hasVolume "29" @default.
- W2398983973 isParatext "false" @default.
- W2398983973 isRetracted "false" @default.
- W2398983973 magId "2398983973" @default.
- W2398983973 workType "article" @default.