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- W2399056104 abstract "AIM To observe the cAMP and adenylyl cyclase (AC) mRNA level in hippocampus of mice with vascular dementia (ischemia/reperfusion), and explore the molecular pathogenesis of ischemia/reperfusion. METHODS The mice were subjected for ischemia/reperfusion three times on bilateral common carotid arteries by knots to establish models of ischemia/reperfusion and the changes of learning and memory were tested on 29 d/30 d after operation. Sham-operation mice were introduced as control group. The cAMP level was evaluated by the radioimmunoassay (RIA), AC mRNA positive neurons of hippocampus CA1 area were dyed through in-situ hybridization (ISH). RESULTS Compared with sham-operation group, the learning and memory of model group was worse (P < 0.05), the cAMP level in hippocampus was lower (P < 0.05) and the surface density (Sv) of AC mRNA positive neurons reduced (P < 0.05). CONCLUSION The lower cAMP and AC mRNA level in hippocampus might participate in the molecular pathogenesis of ischemia/reperfusion." @default.
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- W2399056104 date "2005-08-01" @default.
- W2399056104 modified "2023-09-24" @default.
- W2399056104 title "THE CHANGES OF cAMP AND ADENYLYL CYCLASE mRNA LEVEL IN HIPPOCAMPUS OF MICE WITH ISCHEMIA/REPERFUSION" @default.
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