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- W2399131608 abstract "A high performance liquid chromatography method was developed for the simultaneous separation and quantitation of Atorvastatin calcium and Amlodipine besilate in combined pharmaceutical tablet dosage form. The chromatographic estimation was achieved by using mobile phase consisting of a mixture of phosphate buffer (1ml ortho phosphoric acid in 1000 ml 0f water) acetonitrile and methanol (53:43:4, v/v) at a flow rate of 1 ml/min and UV detection at 246 nm, using photodiode array detector. The determination was carried out by using Grace Smart RP C-18 column (250 X 4.6 mm, 5 µm). The retention time of Amlodipine besilate and Atorvastatin calcium was 3.337 and 6.067 respectively. Amlodipine besilate and Atorvastatin calcium calibration curves were linear with correlation coefficient 0.9989 and 0.9981 over a concentration range of 40-60 µg/ml and 80-120 µg/ml respectively. Recovery was between 99.60-100.02 for AML and 99.05-100.52% for ATV, respectively." @default.
- W2399131608 created "2016-06-24" @default.
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- W2399131608 date "2011-01-01" @default.
- W2399131608 modified "2023-09-27" @default.
- W2399131608 title "ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS DETERMINATION OF ATORVASTATIN CALCIUM AND AMLODIPINE BESILAT IN TABLET DOSAGE FORM BY RP-HPLC" @default.
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