FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399135247> ?p ?o ?g. }

• W2399135247 endingPage "754" @default.
• W2399135247 startingPage "749" @default.
• W2399135247 abstract "ABSTRACT We have examined the role of platelet-derived growth factor (PDGF) ligand and receptor genes in the angiogenic process of the developing human placenta. In situ hybridization analysis of first trimester placentae showed that most microcapillary endothelial cells coexpress the PDGF-B and PDGF β-receptor genes. This observation indicates that PDGF-B may participate in placental angiogenesis by forming autostimulatory loops in capillary endothelial cells to promote cell proliferation. Endothelial cells of macro blood vessels maintained high PDGF-B expression, whereas PDGF β-receptor mRNA was not detectable. In contrast, PDGF β-receptor mRNA was readily detectable in fibroblastlike cells and smooth muscle cells in the surrounding intima of intermediate and macro blood vessels. Taken together, these data suggest that the PDGF-B signalling pathway appears to switch from an autocrine to a paracrine mechanism to stimulate growth of surrounding PDGF β-receptor-positive mesenchymal stromal cells.Smooth muscle cells of the blood vessel intima also expressed the PDGF-A gene, the protein product of which is presumably targeted to the fibroblast-like cells of the mesenchymal stroma as these cells were the only ones expressing the PDGF α-receptor. PDGF-A expression was also detected in columnar cytotrophoblasts where it may have a potential role in stimulating mesenchymal cell growth at the base of the growing placental villi. We discuss the possibility that the regulation of the PDGF-B and β-receptor gene expression might represent the potential targets for primary angiogenic factors." @default.
• W2399135247 created "2016-06-24" @default.
• W2399135247 creator A5047814563 @default.
• W2399135247 creator A5054367458 @default.
• W2399135247 creator A5056059593 @default.
• W2399135247 creator A5079454147 @default.
• W2399135247 date "1991-11-01" @default.
• W2399135247 modified "2023-10-16" @default.
• W2399135247 title "Angiogenesis during human extraembryonic development involves the spatiotemporal control of PDGF ligand and receptor gene expression" @default.
• W2399135247 cites W1551210345 @default.
• W2399135247 cites W1963669837 @default.
• W2399135247 cites W1969702279 @default.
• W2399135247 cites W1982020713 @default.
• W2399135247 cites W1993487598 @default.
• W2399135247 cites W2007245358 @default.
• W2399135247 cites W2009458860 @default.
• W2399135247 cites W2015313106 @default.
• W2399135247 cites W2025529909 @default.
• W2399135247 cites W2028561494 @default.
• W2399135247 cites W2035294169 @default.
• W2399135247 cites W2045956897 @default.
• W2399135247 cites W2061892936 @default.
• W2399135247 cites W2068953892 @default.
• W2399135247 cites W2072808743 @default.
• W2399135247 cites W2080703809 @default.
• W2399135247 cites W2085331160 @default.
• W2399135247 cites W2093101342 @default.
• W2399135247 cites W2112128801 @default.
• W2399135247 cites W2130226121 @default.
• W2399135247 cites W2137260277 @default.
• W2399135247 cites W2148371225 @default.
• W2399135247 cites W4211208200 @default.
• W2399135247 cites W4255042798 @default.
• W2399135247 doi "https://doi.org/10.1242/dev.113.3.749" @default.
• W2399135247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1668277" @default.
• W2399135247 hasPublicationYear "1991" @default.
• W2399135247 type Work @default.
• W2399135247 sameAs 2399135247 @default.
• W2399135247 citedByCount "148" @default.
• W2399135247 countsByYear W23991352472012 @default.
• W2399135247 countsByYear W23991352472013 @default.
• W2399135247 countsByYear W23991352472015 @default.
• W2399135247 countsByYear W23991352472017 @default.
• W2399135247 countsByYear W23991352472019 @default.
• W2399135247 countsByYear W23991352472021 @default.
• W2399135247 countsByYear W23991352472023 @default.
• W2399135247 crossrefType "journal-article" @default.
• W2399135247 hasAuthorship W2399135247A5047814563 @default.
• W2399135247 hasAuthorship W2399135247A5054367458 @default.
• W2399135247 hasAuthorship W2399135247A5056059593 @default.
• W2399135247 hasAuthorship W2399135247A5079454147 @default.
• W2399135247 hasConcept C126322002 @default.
• W2399135247 hasConcept C128240485 @default.
• W2399135247 hasConcept C134018914 @default.
• W2399135247 hasConcept C16930146 @default.
• W2399135247 hasConcept C170493617 @default.
• W2399135247 hasConcept C180361614 @default.
• W2399135247 hasConcept C198826908 @default.
• W2399135247 hasConcept C2775960820 @default.
• W2399135247 hasConcept C2780394083 @default.
• W2399135247 hasConcept C2781294074 @default.
• W2399135247 hasConcept C502942594 @default.
• W2399135247 hasConcept C54355233 @default.
• W2399135247 hasConcept C71924100 @default.
• W2399135247 hasConcept C7876069 @default.
• W2399135247 hasConcept C86803240 @default.
• W2399135247 hasConcept C95444343 @default.
• W2399135247 hasConceptScore W2399135247C126322002 @default.
• W2399135247 hasConceptScore W2399135247C128240485 @default.
• W2399135247 hasConceptScore W2399135247C134018914 @default.
• W2399135247 hasConceptScore W2399135247C16930146 @default.
• W2399135247 hasConceptScore W2399135247C170493617 @default.
• W2399135247 hasConceptScore W2399135247C180361614 @default.
• W2399135247 hasConceptScore W2399135247C198826908 @default.
• W2399135247 hasConceptScore W2399135247C2775960820 @default.
• W2399135247 hasConceptScore W2399135247C2780394083 @default.
• W2399135247 hasConceptScore W2399135247C2781294074 @default.
• W2399135247 hasConceptScore W2399135247C502942594 @default.
• W2399135247 hasConceptScore W2399135247C54355233 @default.
• W2399135247 hasConceptScore W2399135247C71924100 @default.
• W2399135247 hasConceptScore W2399135247C7876069 @default.
• W2399135247 hasConceptScore W2399135247C86803240 @default.
• W2399135247 hasConceptScore W2399135247C95444343 @default.
• W2399135247 hasIssue "3" @default.
• W2399135247 hasLocation W23991352471 @default.
• W2399135247 hasLocation W23991352472 @default.
• W2399135247 hasOpenAccess W2399135247 @default.
• W2399135247 hasPrimaryLocation W23991352471 @default.
• W2399135247 hasRelatedWork W1964803279 @default.
• W2399135247 hasRelatedWork W1968386885 @default.
• W2399135247 hasRelatedWork W1973696220 @default.
• W2399135247 hasRelatedWork W2007967055 @default.
• W2399135247 hasRelatedWork W2025842270 @default.
• W2399135247 hasRelatedWork W2031749466 @default.
• W2399135247 hasRelatedWork W2092554255 @default.
• W2399135247 hasRelatedWork W2099619041 @default.
• W2399135247 hasRelatedWork W2173917538 @default.
• W2399135247 hasRelatedWork W3217787612 @default.

• next