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- W2399219962 abstract "Hypercholesterolemia is a major risk factor for cardiovascular diseases. Serum cholesterol concentrations are regulated by enteral absorption, biliary secretion, and hepatic synthesis. Statins inhibit the rate-limiting enzyme of cholesterol synthesis, HMG-CoA-reductase, and reduce serum cholesterol concentrations as well as cardiovascular morbidity and mortality. Some studies indicate that patients with high baseline cholesterol absorption may show only a small response to statin treatment in terms of cholesterol lowering. Data from genetic association studies and from the IMPROVE-IT trial show that reducing intestinal cholesterol absorption via NCP1L1 further reduces cardiovascular risk. However, some patients do not attain LDL-cholesterol targets on combination therapy. For these patients PCSK9-antibody treatment and lipid-apheresis are options to be considered. This article reviews the current literature on this issue and suggests ‘individualized lipid-lowering therapy’ as an approach to optimize and personalize lipid-lowering treatment of patients with hypercholesterolemia to further reduce residual cardiovascular risk." @default.
- W2399219962 created "2016-06-24" @default.
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- W2399219962 date "2017-05-01" @default.
- W2399219962 modified "2023-10-13" @default.
- W2399219962 title "Individualized lipid-lowering therapy to further reduce residual cardiovascular risk" @default.
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- W2399219962 doi "https://doi.org/10.1016/j.jsbmb.2016.05.016" @default.
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