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- W2399280034 abstract "Significance We conducted a genome-wide screen to identify bacterial factors required for Vibrio parahaemolyticus , an important cause of seafood-borne gastroenteritis, to survive in vitro and colonize the mammalian intestine. Our analysis revealed uncharacterized components of a horizontally acquired type III secretion system linked to virulence (T3SS2) and hundreds of genes that likely contribute to colonization independent of T3SS2. Our work revealed that toxR , a conserved gene in vibrios that governs expression of horizontally acquired virulence factors in Vibrio cholerae , was critical for expression of T3SS2. Thus, expression of disparate virulence-linked elements, acquired via lateral gene transfer in independently evolved pathogenic vibrios, is controlled by a common ancestral transcription factor." @default.
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- W2399280034 date "2016-05-16" @default.
- W2399280034 modified "2023-10-10" @default.
- W2399280034 title "Genetic analysis of <i>Vibrio parahaemolyticus</i> intestinal colonization" @default.
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- W2399280034 doi "https://doi.org/10.1073/pnas.1601718113" @default.
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