Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399323122> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2399323122 endingPage "7" @default.
- W2399323122 startingPage "1013" @default.
- W2399323122 abstract "This study was designed to explore the interactions of alcohol dehydrogenase 1B (ADH1B) rs1229984, aldehyde dehydrogenase 2 (ALDH2)(rs671) and cytochrome P4502E1(CYP2E1)rs1329149 with environmental factors and the interactions between genetic factors in the susceptibility of colorectal cancer (CRC). Roles of genetic factors in the development of colorectal cancer were also studied.With a case-only study design, 472 colorectal cancer cases were enrolled between 2007 and 2009 in this study. Data on demographic characteristics, histories of environmental exposure and clinico-pathological parameters were obtained from all the participants through written questionnaires. Genotypes were determined by Sequenom MassARRAY system. Unconditional logistic regression analysis was employed to explore the gene-environment interactions and gene-gene interactions. χ(2) test and unconditional logistic regression were used to evaluate the roles of polymorphisms on the risk of metastasis to CRC.Overweighted individuals that carrying at least one of the ADH1B rs1229984 G alleles presented significant increase on the risk to colorectal cancer(OR = 1.720, 95%CI:1.038-2.848,ORadj = 1.785, 95%CI:1.061-3.002). Modest interaction was seen between smoking and ADH1B(rs1229984) only before the adjustment of data, by sex, age and drinking status(OR = 0.597, 95% CI:0.387-0.921, ORadj = 0.922, 95%CI:0.509-1.669). Correlations between polymorphisms and the Dukes stage were not found.Overweight presented significant interaction with G allele of ADH1B rs1229984 in the susceptibility of CRC. None of the rs1229984, rs671 and rs1329149 exhibited significant influence on the development of CRC." @default.
- W2399323122 created "2016-06-24" @default.
- W2399323122 creator A5006822602 @default.
- W2399323122 creator A5020306816 @default.
- W2399323122 creator A5039334635 @default.
- W2399323122 creator A5051610166 @default.
- W2399323122 creator A5056833648 @default.
- W2399323122 creator A5063481044 @default.
- W2399323122 creator A5074647986 @default.
- W2399323122 creator A5082363548 @default.
- W2399323122 creator A5090163127 @default.
- W2399323122 date "2013-10-01" @default.
- W2399323122 modified "2023-09-27" @default.
- W2399323122 title "[Role of alcohol-metabolizing enzymes gene polymorphisms and environmental exposure on colorectal cancer: a case-only study]." @default.
- W2399323122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24377999" @default.
- W2399323122 hasPublicationYear "2013" @default.
- W2399323122 type Work @default.
- W2399323122 sameAs 2399323122 @default.
- W2399323122 citedByCount "1" @default.
- W2399323122 countsByYear W23993231222015 @default.
- W2399323122 crossrefType "journal-article" @default.
- W2399323122 hasAuthorship W2399323122A5006822602 @default.
- W2399323122 hasAuthorship W2399323122A5020306816 @default.
- W2399323122 hasAuthorship W2399323122A5039334635 @default.
- W2399323122 hasAuthorship W2399323122A5051610166 @default.
- W2399323122 hasAuthorship W2399323122A5056833648 @default.
- W2399323122 hasAuthorship W2399323122A5063481044 @default.
- W2399323122 hasAuthorship W2399323122A5074647986 @default.
- W2399323122 hasAuthorship W2399323122A5082363548 @default.
- W2399323122 hasAuthorship W2399323122A5090163127 @default.
- W2399323122 hasConcept C104317684 @default.
- W2399323122 hasConcept C121608353 @default.
- W2399323122 hasConcept C126322002 @default.
- W2399323122 hasConcept C143998085 @default.
- W2399323122 hasConcept C151325109 @default.
- W2399323122 hasConcept C151956035 @default.
- W2399323122 hasConcept C180754005 @default.
- W2399323122 hasConcept C181199279 @default.
- W2399323122 hasConcept C2776317432 @default.
- W2399323122 hasConcept C3175096 @default.
- W2399323122 hasConcept C526805850 @default.
- W2399323122 hasConcept C54355233 @default.
- W2399323122 hasConcept C55493867 @default.
- W2399323122 hasConcept C71924100 @default.
- W2399323122 hasConcept C86803240 @default.
- W2399323122 hasConcept C96722902 @default.
- W2399323122 hasConceptScore W2399323122C104317684 @default.
- W2399323122 hasConceptScore W2399323122C121608353 @default.
- W2399323122 hasConceptScore W2399323122C126322002 @default.
- W2399323122 hasConceptScore W2399323122C143998085 @default.
- W2399323122 hasConceptScore W2399323122C151325109 @default.
- W2399323122 hasConceptScore W2399323122C151956035 @default.
- W2399323122 hasConceptScore W2399323122C180754005 @default.
- W2399323122 hasConceptScore W2399323122C181199279 @default.
- W2399323122 hasConceptScore W2399323122C2776317432 @default.
- W2399323122 hasConceptScore W2399323122C3175096 @default.
- W2399323122 hasConceptScore W2399323122C526805850 @default.
- W2399323122 hasConceptScore W2399323122C54355233 @default.
- W2399323122 hasConceptScore W2399323122C55493867 @default.
- W2399323122 hasConceptScore W2399323122C71924100 @default.
- W2399323122 hasConceptScore W2399323122C86803240 @default.
- W2399323122 hasConceptScore W2399323122C96722902 @default.
- W2399323122 hasIssue "10" @default.
- W2399323122 hasLocation W23993231221 @default.
- W2399323122 hasOpenAccess W2399323122 @default.
- W2399323122 hasPrimaryLocation W23993231221 @default.
- W2399323122 hasRelatedWork W1540344649 @default.
- W2399323122 hasRelatedWork W179089402 @default.
- W2399323122 hasRelatedWork W2003484723 @default.
- W2399323122 hasRelatedWork W2045310665 @default.
- W2399323122 hasRelatedWork W2052175101 @default.
- W2399323122 hasRelatedWork W2073226547 @default.
- W2399323122 hasRelatedWork W2131601584 @default.
- W2399323122 hasRelatedWork W2303384523 @default.
- W2399323122 hasRelatedWork W2313455789 @default.
- W2399323122 hasRelatedWork W2336865105 @default.
- W2399323122 hasVolume "34" @default.
- W2399323122 isParatext "false" @default.
- W2399323122 isRetracted "false" @default.
- W2399323122 magId "2399323122" @default.
- W2399323122 workType "article" @default.