Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399359399> ?p ?o ?g. }
- W2399359399 abstract "Transient receptor potential vanilloid 1 (TRPV1) and associated signaling pathways have been reported to be increased in inflammatory pain signaling. There are accumulating evidences surrounding the therapeutic effect of electroacupuncture (EA). EA can reliably attenuate the increase of TRPV1 in mouse inflammatory pain models with unclear signaling mechanisms. Moreover, the difference in the clinical therapeutic effects between using the contralateral and ipsilateral acupoints has been rarely studied. We found that inflammatory pain, which was induced by injecting the complete Freund's adjuvant (CFA), (2.14 ± 0.1, p < 0.05, n = 8) can be alleviated after EA treatment at either ipsilateral (3.91 ± 0.21, p < 0.05, n = 8) or contralateral acupoints (3.79 ± 0.25, p < 0.05, n = 8). EA may also reduce nociceptive Nav sodium currents in dorsal root ganglion (DRG) neurons. The expression of TRPV1 and associated signaling pathways notably increased after the CFA injection; this expression can be further attenuated significantly in EA treatment. TRPV1 and associated signaling pathways can be prevented in TRPV1 knockout mice, suggesting that TRPV1 knockout mice are resistant to inflammatory pain. Through this study, we have increased the understanding of the mechanism that both ipsilateral and contralateral EA might alter TRPV1 and associated signaling pathways to reduce inflammatory pain." @default.
- W2399359399 created "2016-06-24" @default.
- W2399359399 creator A5009962508 @default.
- W2399359399 creator A5028676753 @default.
- W2399359399 creator A5032633956 @default.
- W2399359399 creator A5055877292 @default.
- W2399359399 creator A5081246167 @default.
- W2399359399 date "2016-02-24" @default.
- W2399359399 modified "2023-10-05" @default.
- W2399359399 title "Probing the Effects and Mechanisms of Electroacupuncture at Ipsilateral or Contralateral ST36–ST37 Acupoints on CFA-induced Inflammatory Pain" @default.
- W2399359399 cites W105506365 @default.
- W2399359399 cites W1511198581 @default.
- W2399359399 cites W1530030261 @default.
- W2399359399 cites W1557513385 @default.
- W2399359399 cites W1566814755 @default.
- W2399359399 cites W1919181290 @default.
- W2399359399 cites W1968001136 @default.
- W2399359399 cites W1971128550 @default.
- W2399359399 cites W1971754431 @default.
- W2399359399 cites W1977701887 @default.
- W2399359399 cites W1987208939 @default.
- W2399359399 cites W1992358268 @default.
- W2399359399 cites W1994115933 @default.
- W2399359399 cites W1997308301 @default.
- W2399359399 cites W2007062738 @default.
- W2399359399 cites W2008648558 @default.
- W2399359399 cites W2028380432 @default.
- W2399359399 cites W2030620756 @default.
- W2399359399 cites W2031120956 @default.
- W2399359399 cites W2038164820 @default.
- W2399359399 cites W2043262347 @default.
- W2399359399 cites W2048163567 @default.
- W2399359399 cites W2054024143 @default.
- W2399359399 cites W2061479000 @default.
- W2399359399 cites W2062480940 @default.
- W2399359399 cites W2063259244 @default.
- W2399359399 cites W2068804191 @default.
- W2399359399 cites W2074027763 @default.
- W2399359399 cites W2075632800 @default.
- W2399359399 cites W2077950886 @default.
- W2399359399 cites W2079261707 @default.
- W2399359399 cites W2080289814 @default.
- W2399359399 cites W2082908786 @default.
- W2399359399 cites W2086418412 @default.
- W2399359399 cites W2086475285 @default.
- W2399359399 cites W2087859406 @default.
- W2399359399 cites W2090596393 @default.
- W2399359399 cites W2094323079 @default.
- W2399359399 cites W2104984002 @default.
- W2399359399 cites W2109293109 @default.
- W2399359399 cites W2118626190 @default.
- W2399359399 cites W2122168713 @default.
- W2399359399 cites W2126364141 @default.
- W2399359399 cites W2133113175 @default.
- W2399359399 cites W2134465874 @default.
- W2399359399 cites W2134742719 @default.
- W2399359399 cites W2154855467 @default.
- W2399359399 cites W2156045598 @default.
- W2399359399 cites W2161455727 @default.
- W2399359399 cites W2172261190 @default.
- W2399359399 cites W2180980616 @default.
- W2399359399 cites W2277647632 @default.
- W2399359399 cites W2312146038 @default.
- W2399359399 cites W2418235693 @default.
- W2399359399 cites W794976161 @default.
- W2399359399 doi "https://doi.org/10.1038/srep22123" @default.
- W2399359399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4764889" @default.
- W2399359399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26906464" @default.
- W2399359399 hasPublicationYear "2016" @default.
- W2399359399 type Work @default.
- W2399359399 sameAs 2399359399 @default.
- W2399359399 citedByCount "58" @default.
- W2399359399 countsByYear W23993593992016 @default.
- W2399359399 countsByYear W23993593992017 @default.
- W2399359399 countsByYear W23993593992018 @default.
- W2399359399 countsByYear W23993593992019 @default.
- W2399359399 countsByYear W23993593992020 @default.
- W2399359399 countsByYear W23993593992021 @default.
- W2399359399 countsByYear W23993593992022 @default.
- W2399359399 countsByYear W23993593992023 @default.
- W2399359399 crossrefType "journal-article" @default.
- W2399359399 hasAuthorship W2399359399A5009962508 @default.
- W2399359399 hasAuthorship W2399359399A5028676753 @default.
- W2399359399 hasAuthorship W2399359399A5032633956 @default.
- W2399359399 hasAuthorship W2399359399A5055877292 @default.
- W2399359399 hasAuthorship W2399359399A5081246167 @default.
- W2399359399 hasBestOaLocation W23993593991 @default.
- W2399359399 hasConcept C105702510 @default.
- W2399359399 hasConcept C126322002 @default.
- W2399359399 hasConcept C134018914 @default.
- W2399359399 hasConcept C140530291 @default.
- W2399359399 hasConcept C142724271 @default.
- W2399359399 hasConcept C15490471 @default.
- W2399359399 hasConcept C155164980 @default.
- W2399359399 hasConcept C160145004 @default.
- W2399359399 hasConcept C170493617 @default.
- W2399359399 hasConcept C182704531 @default.
- W2399359399 hasConcept C204787440 @default.
- W2399359399 hasConcept C2776202274 @default.
- W2399359399 hasConcept C2776281502 @default.