FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399366922> ?p ?o ?g. }

• W2399366922 abstract "Several genetic mechanisms have been shown to diversity the expressed antibody repertoire of committed B lymphocytes. These include somatic hypermutation, V gene replacement, and ongoing gene rearrangement. These mechanisms may be operational at discrete points in the B-cell differentiation pathway and may generate idiotypic diversity in various malignant B-cell tumors. Hypermutation of the Ig variable region has been shown to occur in follicular lymphoma, but not in pre-B cell acute lymphoblastic leukemia, Burkitt's lymphoma, chronic lymphocytic leukemia, or myeloma. To study hypermutation in a large cell lymphoma, we use a polymerase chain reaction-based approach, employing consensus VH and JH primers, to clone and sequence rearranged Ig heavy chain variable regions. Neither tumor cells immortalized in rescue fusions nor idiotypic variants of a tumor-derived cell line generated through ongoing lambda light chain gene rearrangements show any significant number of variable region mutations. Thus, at the in vivo stage of B- cell differentiation from which this large cell lymphoma arose, Ig variable region hypermutation was not occurring, nor did it occur during propagation in vitro of these tumor cells. Thus, the window of hypermutation in malignant B-cell tumors is more precisely defined, which may have clinical implications for diagnostic and therapeutic approaches directed at the Ig variable region." @default.
• W2399366922 created "2016-06-24" @default.
• W2399366922 creator A5022593725 @default.
• W2399366922 creator A5044585913 @default.
• W2399366922 creator A5084792996 @default.
• W2399366922 date "1992-08-01" @default.
• W2399366922 modified "2023-10-06" @default.
• W2399366922 title "Absence of immunoglobulin variable region hypermutation in a large cell lymphoma after in vivo and in vitro propagation" @default.
• W2399366922 cites W1508634373 @default.
• W2399366922 cites W1577375575 @default.
• W2399366922 cites W1625382543 @default.
• W2399366922 cites W1675863586 @default.
• W2399366922 cites W1965084149 @default.
• W2399366922 cites W1969398003 @default.
• W2399366922 cites W1981197474 @default.
• W2399366922 cites W1996264489 @default.
• W2399366922 cites W2000107365 @default.
• W2399366922 cites W2002192875 @default.
• W2399366922 cites W2004707654 @default.
• W2399366922 cites W2011825464 @default.
• W2399366922 cites W2014395675 @default.
• W2399366922 cites W2036050361 @default.
• W2399366922 cites W2058766393 @default.
• W2399366922 cites W2068378281 @default.
• W2399366922 cites W2076899085 @default.
• W2399366922 cites W2098977954 @default.
• W2399366922 cites W2104897136 @default.
• W2399366922 cites W2147499495 @default.
• W2399366922 cites W2148855679 @default.
• W2399366922 cites W2161629160 @default.
• W2399366922 cites W2163451755 @default.
• W2399366922 cites W85464595 @default.
• W2399366922 cites W1974596630 @default.
• W2399366922 doi "https://doi.org/10.1182/blood.v80.3.738.bloodjournal803738" @default.
• W2399366922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1638025" @default.
• W2399366922 hasPublicationYear "1992" @default.
• W2399366922 type Work @default.
• W2399366922 sameAs 2399366922 @default.
• W2399366922 citedByCount "4" @default.
• W2399366922 crossrefType "journal-article" @default.
• W2399366922 hasAuthorship W2399366922A5022593725 @default.
• W2399366922 hasAuthorship W2399366922A5044585913 @default.
• W2399366922 hasAuthorship W2399366922A5084792996 @default.
• W2399366922 hasBestOaLocation W23993669221 @default.
• W2399366922 hasConcept C104317684 @default.
• W2399366922 hasConcept C128526571 @default.
• W2399366922 hasConcept C137756551 @default.
• W2399366922 hasConcept C153911025 @default.
• W2399366922 hasConcept C159654299 @default.
• W2399366922 hasConcept C203014093 @default.
• W2399366922 hasConcept C2777058707 @default.
• W2399366922 hasConcept C2777938653 @default.
• W2399366922 hasConcept C2778453870 @default.
• W2399366922 hasConcept C2778461978 @default.
• W2399366922 hasConcept C2779338263 @default.
• W2399366922 hasConcept C2992511266 @default.
• W2399366922 hasConcept C36394416 @default.
• W2399366922 hasConcept C502942594 @default.
• W2399366922 hasConcept C54355233 @default.
• W2399366922 hasConcept C86803240 @default.
• W2399366922 hasConcept C96007430 @default.
• W2399366922 hasConceptScore W2399366922C104317684 @default.
• W2399366922 hasConceptScore W2399366922C128526571 @default.
• W2399366922 hasConceptScore W2399366922C137756551 @default.
• W2399366922 hasConceptScore W2399366922C153911025 @default.
• W2399366922 hasConceptScore W2399366922C159654299 @default.
• W2399366922 hasConceptScore W2399366922C203014093 @default.
• W2399366922 hasConceptScore W2399366922C2777058707 @default.
• W2399366922 hasConceptScore W2399366922C2777938653 @default.
• W2399366922 hasConceptScore W2399366922C2778453870 @default.
• W2399366922 hasConceptScore W2399366922C2778461978 @default.
• W2399366922 hasConceptScore W2399366922C2779338263 @default.
• W2399366922 hasConceptScore W2399366922C2992511266 @default.
• W2399366922 hasConceptScore W2399366922C36394416 @default.
• W2399366922 hasConceptScore W2399366922C502942594 @default.
• W2399366922 hasConceptScore W2399366922C54355233 @default.
• W2399366922 hasConceptScore W2399366922C86803240 @default.
• W2399366922 hasConceptScore W2399366922C96007430 @default.
• W2399366922 hasLocation W23993669221 @default.
• W2399366922 hasOpenAccess W2399366922 @default.
• W2399366922 hasPrimaryLocation W23993669221 @default.
• W2399366922 hasRelatedWork W1508634373 @default.
• W2399366922 hasRelatedWork W1519324480 @default.
• W2399366922 hasRelatedWork W1561809325 @default.
• W2399366922 hasRelatedWork W1675863586 @default.
• W2399366922 hasRelatedWork W1969398003 @default.
• W2399366922 hasRelatedWork W1970759480 @default.
• W2399366922 hasRelatedWork W1998079194 @default.
• W2399366922 hasRelatedWork W2000509813 @default.
• W2399366922 hasRelatedWork W2003231181 @default.
• W2399366922 hasRelatedWork W2005566446 @default.
• W2399366922 hasRelatedWork W2021690185 @default.
• W2399366922 hasRelatedWork W2042497309 @default.
• W2399366922 hasRelatedWork W2091710009 @default.
• W2399366922 hasRelatedWork W2107202569 @default.
• W2399366922 hasRelatedWork W2157577917 @default.
• W2399366922 hasRelatedWork W2165225696 @default.
• W2399366922 hasRelatedWork W2320335243 @default.
• W2399366922 hasRelatedWork W2419070327 @default.
• W2399366922 hasRelatedWork W2461349584 @default.

• next