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• W2399366982 abstract "No AccessJournal of Urology1 Sep 1986Recurrences During the Chemoprophylactic Treatment of Superficial Tumors of the Bladder Valentino Ferraris, Enrico Repetto, Pier Francesco Pisano, and Dante Albano Valentino FerrarisValentino Ferraris More articles by this author , Enrico RepettoEnrico Repetto More articles by this author , Pier Francesco PisanoPier Francesco Pisano More articles by this author , and Dante AlbanoDante Albano More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)44977-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail A total of 88 patients who underwent resection for superficial stages Ta and T1 bladder tumors received chemoprophylactic treatment to prevent recurrence postoperatively. The first 44 patients were given doxorubicin at monthly intervals and the second 44 received doxorubicin plus mitomycin C alternately, with the first 6 instillations at weekly intervals and the rest monthly beginning 1 month after resection. Recurrences during treatment were assessed as an index of drug resistance. Tumor developed while the patients were undergoing treatment (9 to 10 months) in 15.9 per cent (7 of 44) of group 1 patients, 18.1 per cent (8 of 44) of group 2 patients and 17.0 per cent (15 of 88) of the total patients studied. At the initial post-treatment cystoscopy 12 to 16 months later 2 more patients in group 1 and none in group 2 had recognizable tumors. Treatment was continued in patients with recurrences. A total of 41 recurrences in 435 months of followup was recorded, for a rate of 9.42 recurrences per 100 patient-months. No worsening of the histological grading was noted but 2 patients with initial stage T1 disease had subsequent carcinoma in situ. © 1986 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByStewart D, Green R, Futter N, Walsh W, Mckay D, Verma S, Maroun J and Redmond D (2018) Phase I and Pharmacology Study of Intravesical Mitoxantrone for Recurrent Superficial Bladder TumorsJournal of Urology, VOL. 143, NO. 4, (714-716), Online publication date: 1-Apr-1990.Soloway M (2018) Editorial CommentsJournal of Urology, VOL. 143, NO. 4, (716-716), Online publication date: 1-Apr-1990.Lamm D (2018) Editorial CommentsJournal of Urology, VOL. 143, NO. 4, (716-716), Online publication date: 1-Apr-1990. Volume 136Issue 3September 1986Page: 576-579 Advertisement Copyright & Permissions© 1986 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Valentino Ferraris More articles by this author Enrico Repetto More articles by this author Pier Francesco Pisano More articles by this author Dante Albano More articles by this author Expand All Advertisement Loading ..." @default.
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• W2399366982 title "Recurrences During the Chemoprophylactic Treatment of Superficial Tumors of the Bladder" @default.
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