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- W2399367788 abstract "Histamine will alter blood flow and permeability in systemic and cerebral vessels. We reported that intracarotid infusion of histamine selectively increased the blood flow in experimental brain tumours and caused extravassation of Evans blue within tumours. In this study, the effects of histamine on tumour and brain capillary permeability were quantified using autoradiography. RG2 glioma cells were implanted in female Wistar rats. Seven days after implantation, either low doses of histamine (1 or 10 μg kg–1 min–1) or saline as a control was infused through the carotid artery of rats. Regional permeability was measured by autoradiography using [14C] aminoisobutyric acid, and the unidirectional transfer constant, Ki (μl g–1 min–1), was calculated. Intracarotid infusion of 10 μg kg–1 min–1 histamine resulted in significant increase in brain tumour permeability, compared to controls. The permeability, Ki, for the 10 μg kg–1 min–1 histamine group, the 1 μg kg–1 min–1 histamine group, and the control group was 18.8 ± 4.6 (p < 0.05), 14.9 ± 5.2, 13.9 ± 3.7 μl g–1 min–1, respectively. There was no significant change in blood brain permeability in other brain regions. The effect of increased permeability by 10 μg kg–1 min–1 histamine was suppressed by the H2-blocker, cimetidine. This suggests that the effect of histamine on tumour capillaries is mediated by H2-receptors. Intracarotid histamine infusion selectively increases permeability in brain tumours. [Neurol Res 1994; 16: 125-128]" @default.
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- W2399367788 date "1994-04-01" @default.
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- W2399367788 title "Intracarotid histamine infusion increases blood tumour permeability in RG2 glioma" @default.
- W2399367788 doi "https://doi.org/10.1080/01616412.1994.11740209" @default.
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