FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399373676> ?p ?o ?g. }

• W2399373676 abstract "In computer models, we studied instantaneous (time-varying) current-voltage relationships (iIVs) of populations of ion channels characteristic of the membrane of different type excitable cells, of which the responses to electrical stimuli essentially differ: giant squid axon (Hodgkin-Huxley model), cardiomyocyte, dendrites of CA3 hippocampal pyramidal neurons and Purkinje neurons of the cerebellum. The membrane potential was stepped from the rest level to a certain depolarization test level that was clamped for a certain time, and the total current was measured at different moments after the step onset. For each iIV zero-current points (potentials) were determined. A set of such points, which were situated on the limb of iIV positive slop and corresponded to the state of high membrane depolarization (excitation state, upstate) at different time moments, were used to characterize the dynamics of the excitation state in time. With these indicators the axon membrane was characterized by a single excitation state that rapidly occurred (0.25 ms) and was short-lasting (decayed from -45 to 40 mV during life-time of 5.5 ms). There were two such states of the membrane of cardiomyocyte. The first one was early, rapidly occurring and short-living (rapidly relaxing). It occurred shortly after the depolarization start and lasted for 14.5 ms. The second one was late, slowly rising and long-lasting (occurred with a 7.5-ms delay, increased from 11 to 46 mV in 39 ms and then relaxed lasting for 623 ms in total). The dendritic membrane ofCA3 neurons had one long-lasting excitation state that occurred shortly after the depolarization shift, first rapidly relaxed during 3 ms from initial 30 mV level to -10 mV and then slowly, in 80 ms, stabilized at the level of -20 mV. In the Purkinje neuron membrane two short-lasting and one very long-lasting excitation states were revealed. The first state of very high (>100 mV) depolarization relaxed to 4 mV in 0.8 ms. Shortly before its vanishing, at 0.7 ms, the second short-lasting state emerged, which relaxed in 1 ms from -22 mV to -48 mV. At 1.8 ms a new excitation state emerged, which after a transient relaxation stabilized at -29.65 mV starting from 88 ms. Thus, iIVs allowed disclosing a fine organization of the states of electrical excitation of the membrane and revealing, in populations of ion channels of different content, existence of different number of the mentioned states, which differ from each other in occurrence time and life-time." @default.
• W2399373676 created "2016-06-24" @default.
• W2399373676 creator A5002308328 @default.
• W2399373676 creator A5078453814 @default.
• W2399373676 date "2012-06-28" @default.
• W2399373676 modified "2023-09-25" @default.
• W2399373676 title "Dynamical electrical states of heterogeneous populations of ion channels in the membranes of excitable cells" @default.
• W2399373676 cites W1966907489 @default.
• W2399373676 cites W1984336411 @default.
• W2399373676 cites W1985940938 @default.
• W2399373676 cites W1992532194 @default.
• W2399373676 cites W2031008134 @default.
• W2399373676 cites W2050699386 @default.
• W2399373676 cites W2059608691 @default.
• W2399373676 cites W2059715474 @default.
• W2399373676 cites W2060988598 @default.
• W2399373676 cites W2064354742 @default.
• W2399373676 cites W2080082506 @default.
• W2399373676 cites W2117120818 @default.
• W2399373676 doi "https://doi.org/10.15407/fz58.03.050" @default.
• W2399373676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22946313" @default.
• W2399373676 hasPublicationYear "2012" @default.
• W2399373676 type Work @default.
• W2399373676 sameAs 2399373676 @default.
• W2399373676 citedByCount "2" @default.
• W2399373676 countsByYear W23993736762014 @default.
• W2399373676 countsByYear W23993736762015 @default.
• W2399373676 crossrefType "journal-article" @default.
• W2399373676 hasAuthorship W2399373676A5002308328 @default.
• W2399373676 hasAuthorship W2399373676A5078453814 @default.
• W2399373676 hasBestOaLocation W23993736761 @default.
• W2399373676 hasConcept C121332964 @default.
• W2399373676 hasConcept C12554922 @default.
• W2399373676 hasConcept C169760540 @default.
• W2399373676 hasConcept C181911157 @default.
• W2399373676 hasConcept C185592680 @default.
• W2399373676 hasConcept C2779530196 @default.
• W2399373676 hasConcept C4141045 @default.
• W2399373676 hasConcept C62520636 @default.
• W2399373676 hasConcept C83581075 @default.
• W2399373676 hasConcept C86803240 @default.
• W2399373676 hasConceptScore W2399373676C121332964 @default.
• W2399373676 hasConceptScore W2399373676C12554922 @default.
• W2399373676 hasConceptScore W2399373676C169760540 @default.
• W2399373676 hasConceptScore W2399373676C181911157 @default.
• W2399373676 hasConceptScore W2399373676C185592680 @default.
• W2399373676 hasConceptScore W2399373676C2779530196 @default.
• W2399373676 hasConceptScore W2399373676C4141045 @default.
• W2399373676 hasConceptScore W2399373676C62520636 @default.
• W2399373676 hasConceptScore W2399373676C83581075 @default.
• W2399373676 hasConceptScore W2399373676C86803240 @default.
• W2399373676 hasLocation W23993736761 @default.
• W2399373676 hasLocation W23993736762 @default.
• W2399373676 hasOpenAccess W2399373676 @default.
• W2399373676 hasPrimaryLocation W23993736761 @default.
• W2399373676 hasRelatedWork W1986496330 @default.
• W2399373676 hasRelatedWork W1998119819 @default.
• W2399373676 hasRelatedWork W2054589093 @default.
• W2399373676 hasRelatedWork W2083472340 @default.
• W2399373676 hasRelatedWork W2101952786 @default.
• W2399373676 hasRelatedWork W2155718816 @default.
• W2399373676 hasRelatedWork W2307189605 @default.
• W2399373676 hasRelatedWork W233527252 @default.
• W2399373676 hasRelatedWork W2905199711 @default.
• W2399373676 hasRelatedWork W2945709311 @default.
• W2399373676 isParatext "false" @default.
• W2399373676 isRetracted "false" @default.
• W2399373676 magId "2399373676" @default.
• W2399373676 workType "article" @default.