FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399406585> ?p ?o ?g. }

• W2399406585 endingPage "78" @default.
• W2399406585 startingPage "69" @default.
• W2399406585 abstract "For schizophrenia, bipolar disorder, and autism, clinical descriptions are precise and reliable, but there is great overlap among diagnoses in associated genetic polymorphisms and rare variants, treatment response, and other phenomenological findings such as brain imaging. It is widely hoped that new diagnostic categories can be developed which are more precise and predictive of important features of illness, particularly response to pharmacological agents. It is the intent of this paper to describe the diagnostic implications of some current genetic findings, and to describe how the genetic associations with diagnosis may be teased apart into new associations with biologically coherent diagnostic entities and scales, based on the various functional aspects of the associated genes and functional genomic data. Las descripciones clínicas para la esquizofrenia, el trastorno bipolar y el autismo son precisas y confiables, pero hay una gran sobreposición entre estos diagnósticos encuanto a polimorfismos genéticos asociados y variantes raras, respuesta a tratamiento y otros hallazgos como las imágenes cerebrales. Hay grandes expectativas de que se puedan desarrollar nuevas categorías diagnósticas, que sean más precisas y predictoras de las características importantes de la enfermedad, en especial de la respuesta a los fármacos. La intención de este artículo es describir las implicancias diagnósticas de algunos hallazgos genéticos actuales y también describir cómo las asociaciones genéticas con los diagnósticos pueden dar origen a nuevas asociaciones con entidades diagnósticas y escalas biológicamente coherentes, basadas en varios aspectos funcionales de los genes asociados y datos genómicos funcionales.Pour la schizophrénie, les troubles bipolaires et l'autisme, les descriptions cliniques sont précises et fiables, mais il existe un chevauchement important entre ces diagnostics pour les variants rares et les polymorphismes génétiques associés, la réponse au traitement et d'autres symptômes et signes comme l'imagerie cérébrale. De nouvelles catégories diagnostiques plus précises et prédictives des caractéristiques importantes de la maladie, en particulier la réponse aux produits pharmacologiques, sont fortement espérées. Cet article a pour but de décrire les implications diagnostiques de certains résultats génétiques actuels et de décrire comment les associations génétiques observées avec ces catégories diagnostiques peuvent être séparées en de nouvelles associations avec des dimensions et des entités diagnostiques biologiquement cohérentes, à partir des nombreux aspects fonctionnels des gènes associés et des données de génomique fonctionnelle." @default.
• W2399406585 created "2016-06-24" @default.
• W2399406585 creator A5029129951 @default.
• W2399406585 creator A5049316851 @default.
• W2399406585 date "2015-03-31" @default.
• W2399406585 modified "2023-10-18" @default.
• W2399406585 title "Genetic and genomic analyses as a basis for new diagnostic nosologies" @default.
• W2399406585 cites W1560557356 @default.
• W2399406585 cites W1911611740 @default.
• W2399406585 cites W1971321176 @default.
• W2399406585 cites W1973502710 @default.
• W2399406585 cites W1976555450 @default.
• W2399406585 cites W1980991473 @default.
• W2399406585 cites W1981637710 @default.
• W2399406585 cites W1995647101 @default.
• W2399406585 cites W1996124672 @default.
• W2399406585 cites W1997159235 @default.
• W2399406585 cites W2003491970 @default.
• W2399406585 cites W2009742334 @default.
• W2399406585 cites W2033105784 @default.
• W2399406585 cites W2033151532 @default.
• W2399406585 cites W2041467022 @default.
• W2399406585 cites W2045227722 @default.
• W2399406585 cites W2047031939 @default.
• W2399406585 cites W2048648661 @default.
• W2399406585 cites W2049643291 @default.
• W2399406585 cites W2060555434 @default.
• W2399406585 cites W2060705109 @default.
• W2399406585 cites W2069378182 @default.
• W2399406585 cites W2082107430 @default.
• W2399406585 cites W2083045667 @default.
• W2399406585 cites W2083987766 @default.
• W2399406585 cites W2098597355 @default.
• W2399406585 cites W2101357408 @default.
• W2399406585 cites W2106870542 @default.
• W2399406585 cites W2107908180 @default.
• W2399406585 cites W2113381731 @default.
• W2399406585 cites W2115807273 @default.
• W2399406585 cites W2116054884 @default.
• W2399406585 cites W2116753165 @default.
• W2399406585 cites W2116944142 @default.
• W2399406585 cites W2119608950 @default.
• W2399406585 cites W2124534817 @default.
• W2399406585 cites W2124873881 @default.
• W2399406585 cites W2132297623 @default.
• W2399406585 cites W2139852368 @default.
• W2399406585 cites W2150287316 @default.
• W2399406585 cites W2150508161 @default.
• W2399406585 cites W2151820055 @default.
• W2399406585 cites W2151834457 @default.
• W2399406585 cites W2156695919 @default.
• W2399406585 cites W2157401645 @default.
• W2399406585 cites W2161527093 @default.
• W2399406585 cites W2162212014 @default.
• W2399406585 cites W2164690942 @default.
• W2399406585 doi "https://doi.org/10.31887/dcns.2015.17.1/egershon" @default.
• W2399406585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4421903" @default.
• W2399406585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25987865" @default.
• W2399406585 hasPublicationYear "2015" @default.
• W2399406585 type Work @default.
• W2399406585 sameAs 2399406585 @default.
• W2399406585 citedByCount "6" @default.
• W2399406585 countsByYear W23994065852016 @default.
• W2399406585 countsByYear W23994065852017 @default.
• W2399406585 countsByYear W23994065852019 @default.
• W2399406585 countsByYear W23994065852020 @default.
• W2399406585 crossrefType "journal-article" @default.
• W2399406585 hasAuthorship W2399406585A5029129951 @default.
• W2399406585 hasAuthorship W2399406585A5049316851 @default.
• W2399406585 hasBestOaLocation W23994065851 @default.
• W2399406585 hasConcept C104317684 @default.
• W2399406585 hasConcept C118552586 @default.
• W2399406585 hasConcept C135763542 @default.
• W2399406585 hasConcept C142724271 @default.
• W2399406585 hasConcept C153209595 @default.
• W2399406585 hasConcept C15744967 @default.
• W2399406585 hasConcept C169760540 @default.
• W2399406585 hasConcept C169900460 @default.
• W2399406585 hasConcept C186413461 @default.
• W2399406585 hasConcept C205778803 @default.
• W2399406585 hasConcept C2776174506 @default.
• W2399406585 hasConcept C2776412080 @default.
• W2399406585 hasConcept C2994403141 @default.
• W2399406585 hasConcept C534262118 @default.
• W2399406585 hasConcept C54355233 @default.
• W2399406585 hasConcept C58693492 @default.
• W2399406585 hasConcept C71924100 @default.
• W2399406585 hasConcept C86803240 @default.
• W2399406585 hasConceptScore W2399406585C104317684 @default.
• W2399406585 hasConceptScore W2399406585C118552586 @default.
• W2399406585 hasConceptScore W2399406585C135763542 @default.
• W2399406585 hasConceptScore W2399406585C142724271 @default.
• W2399406585 hasConceptScore W2399406585C153209595 @default.
• W2399406585 hasConceptScore W2399406585C15744967 @default.
• W2399406585 hasConceptScore W2399406585C169760540 @default.
• W2399406585 hasConceptScore W2399406585C169900460 @default.
• W2399406585 hasConceptScore W2399406585C186413461 @default.
• W2399406585 hasConceptScore W2399406585C205778803 @default.

• next