Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399456768> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2399456768 endingPage "362" @default.
- W2399456768 startingPage "356" @default.
- W2399456768 abstract "The effects of inhibiting angiotensin converting enzyme with perindopril and aldosterone with spironolactone were tested in hypertensive patients over fifty. Accordingly, 75 patients with mild hypertension aged 50 to 70 were randomly divided into three groups for a double-blind 8 week comparison of the actions of placebo, 4 to 8 m g / d a y perindopril, and 37.5 to 75 mg/day spironolactone. Side-effects caused one patient to withdraw from placebo and one from spironolactone treatment. Mean blood pressure rose by 2.4 mm Hg after placebo but dropped by 7.4 and 8.6 after perindopril and spironolactone < .01). Placebo, perindopril, and spironolactone did not alter blood glucose or plasma potassium, but induced, respectively, variations of -0.09 , 0, and +0.34 mmol/L in cholesterol (P = .04), and -0.02 , -0.05 , and +0.27 mmol/L in triglycerides < .01). After the three treatments, changes in angiotensin converting enzyme activity averaged ‒1 , ‒6 , and ‒1 mU/mL < .01), in active renin ‒2 , +18, and + 28 pg/mL < .01), and in aldosterone, +15, +8 , and +95 pg/mL < .01). Placebo, perindopril, and spironolactone did not alter microalbuminuria, but reduced urinary kallikrein activity by 0.9, 1.8, and 5.4 mU/mmol creatinine (P = .04). Although short-term administration of spironolactone raised renin and aldosterone markedly and lipids moderately (possibly because of volume contraction), the present results show that perindopril and spironolactone are both safe and effective for treating hypertension at the age of 50 or older. Am J Hypertens 1991;4:356–362" @default.
- W2399456768 created "2016-06-24" @default.
- W2399456768 creator A5015894393 @default.
- W2399456768 creator A5023912786 @default.
- W2399456768 creator A5077449453 @default.
- W2399456768 creator A5087434542 @default.
- W2399456768 date "1991-04-01" @default.
- W2399456768 modified "2023-10-18" @default.
- W2399456768 title "Are Angiotensin Converting Enzyme Inhibition and Aldosterone Antagonism Equivalent in Hypertensive Patients Over Fifty?" @default.
- W2399456768 doi "https://doi.org/10.1093/ajh/4.4.356" @default.
- W2399456768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2059395" @default.
- W2399456768 hasPublicationYear "1991" @default.
- W2399456768 type Work @default.
- W2399456768 sameAs 2399456768 @default.
- W2399456768 citedByCount "9" @default.
- W2399456768 countsByYear W23994567682013 @default.
- W2399456768 countsByYear W23994567682016 @default.
- W2399456768 countsByYear W23994567682017 @default.
- W2399456768 countsByYear W23994567682018 @default.
- W2399456768 crossrefType "journal-article" @default.
- W2399456768 hasAuthorship W2399456768A5015894393 @default.
- W2399456768 hasAuthorship W2399456768A5023912786 @default.
- W2399456768 hasAuthorship W2399456768A5077449453 @default.
- W2399456768 hasAuthorship W2399456768A5087434542 @default.
- W2399456768 hasConcept C126322002 @default.
- W2399456768 hasConcept C134018914 @default.
- W2399456768 hasConcept C138976137 @default.
- W2399456768 hasConcept C142724271 @default.
- W2399456768 hasConcept C198710026 @default.
- W2399456768 hasConcept C204787440 @default.
- W2399456768 hasConcept C27081682 @default.
- W2399456768 hasConcept C2776379505 @default.
- W2399456768 hasConcept C2777097880 @default.
- W2399456768 hasConcept C2778525890 @default.
- W2399456768 hasConcept C2779200603 @default.
- W2399456768 hasConcept C71924100 @default.
- W2399456768 hasConcept C84393581 @default.
- W2399456768 hasConceptScore W2399456768C126322002 @default.
- W2399456768 hasConceptScore W2399456768C134018914 @default.
- W2399456768 hasConceptScore W2399456768C138976137 @default.
- W2399456768 hasConceptScore W2399456768C142724271 @default.
- W2399456768 hasConceptScore W2399456768C198710026 @default.
- W2399456768 hasConceptScore W2399456768C204787440 @default.
- W2399456768 hasConceptScore W2399456768C27081682 @default.
- W2399456768 hasConceptScore W2399456768C2776379505 @default.
- W2399456768 hasConceptScore W2399456768C2777097880 @default.
- W2399456768 hasConceptScore W2399456768C2778525890 @default.
- W2399456768 hasConceptScore W2399456768C2779200603 @default.
- W2399456768 hasConceptScore W2399456768C71924100 @default.
- W2399456768 hasConceptScore W2399456768C84393581 @default.
- W2399456768 hasIssue "4_Pt_1" @default.
- W2399456768 hasLocation W23994567681 @default.
- W2399456768 hasLocation W23994567682 @default.
- W2399456768 hasOpenAccess W2399456768 @default.
- W2399456768 hasPrimaryLocation W23994567681 @default.
- W2399456768 hasRelatedWork W1964285753 @default.
- W2399456768 hasRelatedWork W1967336868 @default.
- W2399456768 hasRelatedWork W2012977668 @default.
- W2399456768 hasRelatedWork W2016647631 @default.
- W2399456768 hasRelatedWork W2027429917 @default.
- W2399456768 hasRelatedWork W2047608102 @default.
- W2399456768 hasRelatedWork W2077998387 @default.
- W2399456768 hasRelatedWork W2177682625 @default.
- W2399456768 hasRelatedWork W2296889994 @default.
- W2399456768 hasRelatedWork W2382651085 @default.
- W2399456768 hasVolume "4" @default.
- W2399456768 isParatext "false" @default.
- W2399456768 isRetracted "false" @default.
- W2399456768 magId "2399456768" @default.
- W2399456768 workType "article" @default.