FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399509676> ?p ?o ?g. }

• W2399509676 endingPage "8" @default.
• W2399509676 startingPage "22" @default.
• W2399509676 abstract "Angiogenesis plays an important role in tumour growth, progression and invasiveness. Vascular endothelial growth factor (VEGF) is a recognised angiogenesis-stimulating factor. Soluble VEGF receptors (sVEGFRs) have antiangiogenic properties. Recent studies have indicated that serum concentrations of these factors show a good correlation with the aggressiveness of these tumours in various organs. The aim of this study was to assess the usefulness of determining serum concentrations of VEGF and sVEGFR-2 in patients with adrenal incidentalomas.The study included 51 patients: 38 women aged 53.57 ± 10.12 years and 13 men aged 54.66 ± 12.73 years without a history of cancer but with non-functioning adrenal tumours incidentally detected on a CT scan. The analysis of the CT images included such morphological features of the tumour as: tumour size, tumour homogenicity, tumour density before and after administration of an intravenous contrast medium, and the value of percentage washout of the contrast medium from the tumour. Based on the above criteria, we identified a group of 40 patients with adrenal tumours who met the CT criteria for benign adenomas (Group 1) and 11 patients whose incidentally discovered tumours did not meet the radiological criteria for benign adenomas, thereby providing grounds for referring these patients for surgery (Group 2). The control group consisted of 20 healthy sex- and age-matched individuals.The mean serum concentrations of VEGF in the study and control groups were similar, although patients with adrenal tumours had significantly higher concentrations of sVEGFR-2 than healthy individuals. There were no significant differences in the mean concentrations of VEGF and sVEGFR-2 between the patients undergoing surgery (Group 2) and the patients not undergoing surgery (Group 1), or between the patients undergoing surgery (Group 2) and the control group. Postoperative histopathology of the resected adrenal tumours revealed benign adrenocortical adenoma in eight patients and the following in the remaining patients: adrenocortical carcinoma in one patient, phaeochromocytoma in one patient and ganglioneuroma in one patient. The adrenocortical carcinoma patient had the highest concentration of VEGF, while this patient's concentration of sVEGFR-2 was the lowest in the study group. In the patients diagnosed with ganglioneuroma and phaeochromocytoma, VEGF and sVEGFR-2 concentrations did not differ significantly from their mean concentrations in the study group. There were also no relationships between the serum concentrations of VEGF or sVEGFR-2 and the following parameters: tumour size, precontrast and postcontrast tumour densities or the value of percentage washout. Positive correlations were, however, identified between the concentration of VEGF and the concentrations of total cholesterol and LDL-cholesterol.Determining the serum concentrations of such angiogenesis markers as VEGF and sVEGFR-2 seems useful in the evaluation of the nature of incidentally detected adrenal masses (incidentalomas), especially in the preoperative differential diagnosis of adrenal masses that do not meet the CT criteria for benign tumours." @default.
• W2399509676 created "2016-06-24" @default.
• W2399509676 creator A5003314722 @default.
• W2399509676 creator A5011791445 @default.
• W2399509676 creator A5022666200 @default.
• W2399509676 creator A5033144279 @default.
• W2399509676 creator A5053698057 @default.
• W2399509676 creator A5074707278 @default.
• W2399509676 creator A5078343737 @default.
• W2399509676 date "2012-01-01" @default.
• W2399509676 modified "2023-10-17" @default.
• W2399509676 title "The usefulness of determining the serum concentrations of vascular endothelial growth factor (VEGF) and its soluble receptor type 2 (sVEGF-2) in the differential diagnosis of adrenal incidentalomas." @default.
• W2399509676 cites W152882861 @default.
• W2399509676 cites W153934429 @default.
• W2399509676 cites W189480869 @default.
• W2399509676 cites W1982246723 @default.
• W2399509676 cites W1992652357 @default.
• W2399509676 cites W2000292756 @default.
• W2399509676 cites W2018257960 @default.
• W2399509676 cites W2033710219 @default.
• W2399509676 cites W2037761545 @default.
• W2399509676 cites W2073541423 @default.
• W2399509676 cites W2077129920 @default.
• W2399509676 cites W2104376522 @default.
• W2399509676 cites W2108376158 @default.
• W2399509676 cites W2116468239 @default.
• W2399509676 cites W2117360867 @default.
• W2399509676 cites W2130926356 @default.
• W2399509676 cites W2136164818 @default.
• W2399509676 cites W2141145436 @default.
• W2399509676 cites W2142173484 @default.
• W2399509676 cites W2164507896 @default.
• W2399509676 cites W2166573361 @default.
• W2399509676 cites W2267519121 @default.
• W2399509676 cites W2324593222 @default.
• W2399509676 cites W2406296374 @default.
• W2399509676 cites W2416075791 @default.
• W2399509676 cites W2436958013 @default.
• W2399509676 cites W2469331674 @default.
• W2399509676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22378094" @default.
• W2399509676 hasPublicationYear "2012" @default.
• W2399509676 type Work @default.
• W2399509676 sameAs 2399509676 @default.
• W2399509676 citedByCount "3" @default.
• W2399509676 countsByYear W23995096762014 @default.
• W2399509676 countsByYear W23995096762018 @default.
• W2399509676 countsByYear W23995096762020 @default.
• W2399509676 crossrefType "journal-article" @default.
• W2399509676 hasAuthorship W2399509676A5003314722 @default.
• W2399509676 hasAuthorship W2399509676A5011791445 @default.
• W2399509676 hasAuthorship W2399509676A5022666200 @default.
• W2399509676 hasAuthorship W2399509676A5033144279 @default.
• W2399509676 hasAuthorship W2399509676A5053698057 @default.
• W2399509676 hasAuthorship W2399509676A5074707278 @default.
• W2399509676 hasAuthorship W2399509676A5078343737 @default.
• W2399509676 hasConcept C126322002 @default.
• W2399509676 hasConcept C142724271 @default.
• W2399509676 hasConcept C167734588 @default.
• W2399509676 hasConcept C2777025900 @default.
• W2399509676 hasConcept C2780394083 @default.
• W2399509676 hasConcept C2780801072 @default.
• W2399509676 hasConcept C71924100 @default.
• W2399509676 hasConcept C90924648 @default.
• W2399509676 hasConceptScore W2399509676C126322002 @default.
• W2399509676 hasConceptScore W2399509676C142724271 @default.
• W2399509676 hasConceptScore W2399509676C167734588 @default.
• W2399509676 hasConceptScore W2399509676C2777025900 @default.
• W2399509676 hasConceptScore W2399509676C2780394083 @default.
• W2399509676 hasConceptScore W2399509676C2780801072 @default.
• W2399509676 hasConceptScore W2399509676C71924100 @default.
• W2399509676 hasConceptScore W2399509676C90924648 @default.
• W2399509676 hasIssue "1" @default.
• W2399509676 hasLocation W23995096761 @default.
• W2399509676 hasOpenAccess W2399509676 @default.
• W2399509676 hasPrimaryLocation W23995096761 @default.
• W2399509676 hasRelatedWork W109317992 @default.
• W2399509676 hasRelatedWork W2005323044 @default.
• W2399509676 hasRelatedWork W2028572934 @default.
• W2399509676 hasRelatedWork W2052274533 @default.
• W2399509676 hasRelatedWork W2128881820 @default.
• W2399509676 hasRelatedWork W2349613211 @default.
• W2399509676 hasRelatedWork W2396486584 @default.
• W2399509676 hasRelatedWork W2563451996 @default.
• W2399509676 hasRelatedWork W2747054008 @default.
• W2399509676 hasRelatedWork W4235312508 @default.
• W2399509676 hasVolume "63" @default.
• W2399509676 isParatext "false" @default.
• W2399509676 isRetracted "false" @default.
• W2399509676 magId "2399509676" @default.
• W2399509676 workType "article" @default.