FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399536632> ?p ?o ?g. }

• W2399536632 endingPage "592" @default.
• W2399536632 startingPage "575" @default.
• W2399536632 abstract "Rapid growth in the field of stem cell research has generated a lot of interest in their therapeutic use, especially in the treatment of neurodegenerative diseases. Specifically, human neural progenitor cells (hNPCs), unique in their capability to differentiate into cells of the neural lineage, have been widely investigated due to their ability to survive, thrive, and migrate toward injured tissues. Still, one of the major roadblocks for clinical applicability arises from the inability to monitor these cells following transplantation. Molecular imaging techniques, such as magnetic resonance imaging (MRI), have been explored to assess hNPC transplant location, migration, and survival. Here we investigated whether inducing hNPCs to overexpress ferritin (hNPCs Fer ), an iron storage protein, is sufficient to track these cells long term in the rat striatum using MRI. We found that increased hypointensity on MRI images could establish hNPC Fer location. Unexpectedly, however, wild-type hNPC transplants were detected in a similar manner, which is likely due to increased iron accumulation following transplantation-induced damage. Hence, we labeled hNPCs with superparamagnetic iron oxide (SPIO) nanoparticles to further increase iron content in an attempt to enhance cell contrast in MRI. SPIO-labeling of hNPCs (hNPCs-SPIO) achieved increased hypointensity, with significantly greater area of decreased T2* compared to hNPC Fer ( p < 0.0001) and all other controls used. However, none of the techniques could be used to determine graft rejection in vivo, which is imperative for understanding cell behavior following transplantation. We conclude that in order for cell survival to be monitored in preclinical and clinical settings, another molecular imaging technique must be employed, including perhaps multimodal imaging, which would utilize MRI along with another imaging modality." @default.
• W2399536632 created "2016-06-24" @default.
• W2399536632 creator A5023600216 @default.
• W2399536632 creator A5027419951 @default.
• W2399536632 creator A5041571478 @default.
• W2399536632 creator A5056658961 @default.
• W2399536632 creator A5067269462 @default.
• W2399536632 creator A5067326029 @default.
• W2399536632 creator A5076105306 @default.
• W2399536632 creator A5082020623 @default.
• W2399536632 creator A5090108909 @default.
• W2399536632 date "2016-03-01" @default.
• W2399536632 modified "2023-10-14" @default.
• W2399536632 title "In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Magnetic Resonance Imaging is Not Enhanced by Ferritin Expression" @default.
• W2399536632 cites W1503270785 @default.
• W2399536632 cites W1543687525 @default.
• W2399536632 cites W1729803168 @default.
• W2399536632 cites W1874831549 @default.
• W2399536632 cites W1966100398 @default.
• W2399536632 cites W1966530560 @default.
• W2399536632 cites W1969296748 @default.
• W2399536632 cites W1969558151 @default.
• W2399536632 cites W1972311486 @default.
• W2399536632 cites W1973456315 @default.
• W2399536632 cites W1977450644 @default.
• W2399536632 cites W1977530922 @default.
• W2399536632 cites W1977907679 @default.
• W2399536632 cites W1982580798 @default.
• W2399536632 cites W1987119816 @default.
• W2399536632 cites W1995611679 @default.
• W2399536632 cites W1997372388 @default.
• W2399536632 cites W2000612944 @default.
• W2399536632 cites W2003441643 @default.
• W2399536632 cites W2004283265 @default.
• W2399536632 cites W2013606687 @default.
• W2399536632 cites W2014649492 @default.
• W2399536632 cites W2021484952 @default.
• W2399536632 cites W2022607018 @default.
• W2399536632 cites W2028250171 @default.
• W2399536632 cites W2033032660 @default.
• W2399536632 cites W2033138320 @default.
• W2399536632 cites W2039779463 @default.
• W2399536632 cites W2041178795 @default.
• W2399536632 cites W2041463273 @default.
• W2399536632 cites W2043289078 @default.
• W2399536632 cites W2046521512 @default.
• W2399536632 cites W2047998625 @default.
• W2399536632 cites W2057962057 @default.
• W2399536632 cites W2060218693 @default.
• W2399536632 cites W2063649608 @default.
• W2399536632 cites W2074673207 @default.
• W2399536632 cites W2076117507 @default.
• W2399536632 cites W2077041460 @default.
• W2399536632 cites W2083877042 @default.
• W2399536632 cites W2084032823 @default.
• W2399536632 cites W2085112737 @default.
• W2399536632 cites W2086567353 @default.
• W2399536632 cites W2087081786 @default.
• W2399536632 cites W2088742448 @default.
• W2399536632 cites W2100876449 @default.
• W2399536632 cites W2117058176 @default.
• W2399536632 cites W2122748778 @default.
• W2399536632 cites W2124331425 @default.
• W2399536632 cites W2136310938 @default.
• W2399536632 cites W2140161317 @default.
• W2399536632 cites W2149897233 @default.
• W2399536632 cites W2150994376 @default.
• W2399536632 cites W2163465346 @default.
• W2399536632 cites W2164324123 @default.
• W2399536632 cites W2170661153 @default.
• W2399536632 cites W2321304109 @default.
• W2399536632 cites W2332111100 @default.
• W2399536632 cites W2341343882 @default.
• W2399536632 cites W4232375721 @default.
• W2399536632 doi "https://doi.org/10.3727/096368915x688614" @default.
• W2399536632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5052815" @default.
• W2399536632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26160767" @default.
• W2399536632 hasPublicationYear "2016" @default.
• W2399536632 type Work @default.
• W2399536632 sameAs 2399536632 @default.
• W2399536632 citedByCount "22" @default.
• W2399536632 countsByYear W23995366322016 @default.
• W2399536632 countsByYear W23995366322017 @default.
• W2399536632 countsByYear W23995366322018 @default.
• W2399536632 countsByYear W23995366322019 @default.
• W2399536632 countsByYear W23995366322020 @default.
• W2399536632 countsByYear W23995366322022 @default.
• W2399536632 countsByYear W23995366322023 @default.
• W2399536632 crossrefType "journal-article" @default.
• W2399536632 hasAuthorship W2399536632A5023600216 @default.
• W2399536632 hasAuthorship W2399536632A5027419951 @default.
• W2399536632 hasAuthorship W2399536632A5041571478 @default.
• W2399536632 hasAuthorship W2399536632A5056658961 @default.
• W2399536632 hasAuthorship W2399536632A5067269462 @default.
• W2399536632 hasAuthorship W2399536632A5067326029 @default.
• W2399536632 hasAuthorship W2399536632A5076105306 @default.
• W2399536632 hasAuthorship W2399536632A5082020623 @default.
• W2399536632 hasAuthorship W2399536632A5090108909 @default.

• next