FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399560959> ?p ?o ?g. }

• W2399560959 endingPage "77" @default.
• W2399560959 startingPage "68" @default.
• W2399560959 abstract "Abstract Neonatal CD4+ T cells have traditionally been viewed as deficient in their capacity to produce Th1 cytokines in response to polyclonal or Ag-specific stimuli. Thus, defining unique aspects of CD4+ T cell activation and development into Th1 effector cells in neonates is essential to the successful development of novel vaccines and immunotherapies to protect infants from intracellular pathogens. Using highly purified naive CD4+ T cells derived from cord and adult peripheral blood, we compared the impact of anti-CD3 stimulation plus costimulation through TLR-2 performed in the absence of APC on CD4+ T cell cytokine production, proliferation, and expression of activation markers. In both age groups, TLR-2 costimulation elicited activation of naive CD4+ T cells, characterized by robust production of IL-2 as well as key Th1-type cytokines IFN-γ and TNF-α. TLR-2 costimulation also dramatically reduced naive T cell production of the immunosuppressive cytokine IL-10. We observed that neonatal naive CD4+ T cells are uniquely sensitive to TLR-2–mediated costimulation, which enabled them to produce equivalent amounts of IFN-γ and more IL-2 when compared with adult responses. Thus, neonatal CD4+ T cells have a distinctive propensity to use TLR-2–mediated costimulation for development into proinflammatory Th1 effectors, and interventions that target CD4+ T cell TLR-2–mediated responses may be exploited to enhance neonatal adaptive immunity." @default.
• W2399560959 created "2016-06-24" @default.
• W2399560959 creator A5012742050 @default.
• W2399560959 creator A5029065307 @default.
• W2399560959 creator A5046479705 @default.
• W2399560959 creator A5048853375 @default.
• W2399560959 creator A5053120757 @default.
• W2399560959 date "2016-07-01" @default.
• W2399560959 modified "2023-10-10" @default.
• W2399560959 title "Direct TLR-2 Costimulation Unmasks the Proinflammatory Potential of Neonatal CD4+ T Cells" @default.
• W2399560959 cites W1484285187 @default.
• W2399560959 cites W1495069464 @default.
• W2399560959 cites W1544940018 @default.
• W2399560959 cites W1546723842 @default.
• W2399560959 cites W1561607361 @default.
• W2399560959 cites W1586897675 @default.
• W2399560959 cites W1597170724 @default.
• W2399560959 cites W1597845391 @default.
• W2399560959 cites W1599185640 @default.
• W2399560959 cites W1655860314 @default.
• W2399560959 cites W1770811198 @default.
• W2399560959 cites W1915217100 @default.
• W2399560959 cites W1927121266 @default.
• W2399560959 cites W1940173921 @default.
• W2399560959 cites W1967285191 @default.
• W2399560959 cites W1974208182 @default.
• W2399560959 cites W1987536937 @default.
• W2399560959 cites W2002604831 @default.
• W2399560959 cites W2003807404 @default.
• W2399560959 cites W2005599815 @default.
• W2399560959 cites W2005689995 @default.
• W2399560959 cites W2007530221 @default.
• W2399560959 cites W2017120500 @default.
• W2399560959 cites W2018311892 @default.
• W2399560959 cites W2018706148 @default.
• W2399560959 cites W2019576909 @default.
• W2399560959 cites W2022612163 @default.
• W2399560959 cites W2034268908 @default.
• W2399560959 cites W2045006755 @default.
• W2399560959 cites W2049270233 @default.
• W2399560959 cites W2054329126 @default.
• W2399560959 cites W2057121293 @default.
• W2399560959 cites W2059274166 @default.
• W2399560959 cites W2063120378 @default.
• W2399560959 cites W2068159181 @default.
• W2399560959 cites W2070095638 @default.
• W2399560959 cites W2089152824 @default.
• W2399560959 cites W2089689912 @default.
• W2399560959 cites W2102143593 @default.
• W2399560959 cites W2105864815 @default.
• W2399560959 cites W2111418333 @default.
• W2399560959 cites W2115617484 @default.
• W2399560959 cites W2116092893 @default.
• W2399560959 cites W2124828758 @default.
• W2399560959 cites W2125221059 @default.
• W2399560959 cites W2131422659 @default.
• W2399560959 cites W2133953064 @default.
• W2399560959 cites W2139150306 @default.
• W2399560959 cites W2144796561 @default.
• W2399560959 cites W2160675125 @default.
• W2399560959 cites W2163798162 @default.
• W2399560959 cites W2189240570 @default.
• W2399560959 cites W2346466553 @default.
• W2399560959 cites W235177795 @default.
• W2399560959 cites W2409022713 @default.
• W2399560959 cites W4313313502 @default.
• W2399560959 doi "https://doi.org/10.4049/jimmunol.1501297" @default.
• W2399560959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5023071" @default.
• W2399560959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27194790" @default.
• W2399560959 hasPublicationYear "2016" @default.
• W2399560959 type Work @default.
• W2399560959 sameAs 2399560959 @default.
• W2399560959 citedByCount "22" @default.
• W2399560959 countsByYear W23995609592017 @default.
• W2399560959 countsByYear W23995609592018 @default.
• W2399560959 countsByYear W23995609592019 @default.
• W2399560959 countsByYear W23995609592020 @default.
• W2399560959 countsByYear W23995609592021 @default.
• W2399560959 countsByYear W23995609592022 @default.
• W2399560959 countsByYear W23995609592023 @default.
• W2399560959 crossrefType "journal-article" @default.
• W2399560959 hasAuthorship W2399560959A5012742050 @default.
• W2399560959 hasAuthorship W2399560959A5029065307 @default.
• W2399560959 hasAuthorship W2399560959A5046479705 @default.
• W2399560959 hasAuthorship W2399560959A5048853375 @default.
• W2399560959 hasAuthorship W2399560959A5053120757 @default.
• W2399560959 hasBestOaLocation W23995609591 @default.
• W2399560959 hasConcept C154317977 @default.
• W2399560959 hasConcept C164027704 @default.
• W2399560959 hasConcept C19317047 @default.
• W2399560959 hasConcept C193419808 @default.
• W2399560959 hasConcept C202751555 @default.
• W2399560959 hasConcept C203014093 @default.
• W2399560959 hasConcept C2775982045 @default.
• W2399560959 hasConcept C2776090121 @default.
• W2399560959 hasConcept C2776914184 @default.
• W2399560959 hasConcept C2778690821 @default.
• W2399560959 hasConcept C55493867 @default.

• next