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• W2399565561 endingPage "2581" @default.
• W2399565561 startingPage "2574" @default.
• W2399565561 abstract "Wang, Yue, Michael J. Rowan, and Roger Anwyl. LTP induction dependent on activation of Ni 2+ -sensitive voltage-gated calcium channels, but not NMDA receptors, in the rat dentate gyrus in vitro. J. Neurophysiol. 78: 2574–2581, 1997. A N-methyl-d-aspartate receptor (NMDAR)-independent long-term potentiation (LTP) has been investigated in the dentate gyrus of the hippocampus in vitro in the presence of the NMDAR antagonist, d-2-amino-phosphonopentanoate (50–100 μM), at a concentration thatcompletely blocked NMDAR-mediated excitatory postsynaptic currents (EPSCs). LTP of patch-clamped EPSCs was induced by pairing low-frequency evoked EPSCs (1 Hz) with depolarizing voltage pulses designed to predominately open low-voltage–activated (LVA) Ca 2+ channels. Voltage pulses alone induced only a short-term potentiation. The LTP was blocked by intracellular application of the rapid Ca 2+ chelator bis-( o-aminophenoxy)- N,N,N′,N′-tetraacetic acid, demonstrating that a rise in intracellular Ca 2+ is required for the NMDAR-independent LTP induction. The NMDAR-independent LTP induction also was blocked by Ni 2+ at a low extracellular concentration (50 μM), which is known to strongly block LVA Ca 2+ channels. However, Ni 2+ did not inhibit the NMDAR-dependent LTP induced by high-frequency stimulation (HFS). The NMDAR-independent LTP induction was not blocked by high concentrations of the L-type Ca 2+ channel blocker nifedipine (10 μM). The NMDAR-independent LTP was inhibited by the metabotropic glutamate receptor ligand (+)-α-methyl-4-carboxyphenylglycine. These experiments demonstrate the presence of a NMDAR-independent LTP induced by Ca 2+ influx via Ni 2+ -sensitive, nifedipine-insensitive voltage-gated Ca 2+ channels, probably LVA Ca 2+ channels. Induction of the NMDAR-independent LTP was inhibited by prior induction of HFS-induced NMDAR-dependent LTP, demonstrating that although the NMDAR-dependent and NMDAR-independent LTP use a different Ca 2+ channel for Ca 2+ influx, they share a common intracellular pathway." @default.
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• W2399565561 date "1997-11-01" @default.
• W2399565561 modified "2023-10-18" @default.
• W2399565561 title "LTP Induction Dependent on Activation of Ni²⁺-Sensitive Voltage-Gated Calcium Channels, but not NMDA Receptors, in the Rat Dentate Gyrus In Vitro" @default.
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• W2399565561 doi "https://doi.org/10.1152/jn.1997.78.5.2574" @default.
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