Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399607088> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2399607088 endingPage "C956" @default.
- W2399607088 startingPage "C946" @default.
- W2399607088 abstract "Radioactive tracers and a modified capacitance-probe technique were used to characterize the mechanisms that mediate Cl and fluid absorption across the bullfrog retinal pigment epithelium (RPE)-choroid. In control (HCO3/CO2) Ringer solution, 36Cl was actively absorbed (retina to choroid) at a mean rate of 0.34 mu eq.cm-2.h-1 (n = 34) and accounted for approximately 25% of the short-circuit current. Apical bumetanide (100 microM) or basal 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS; 1 mM) inhibited active Cl transport by 70 and 62%, respectively. Active Cl absorption was doubled, either by removing HCO3 from the bathing media or by elevating CO2 from 5 to 13%, and the increased flux was inhibited by apical bumetanide or basal DIDS. Open-circuit measurements of fluid absorption rate (Jv) and the net fluxes of 36Cl, 22Na, and 86Rb (K substitute) indicated that CO2-induced acidification stimulated NaCl and fluid absorption across the RPE. During acidification, bumetanide produced a twofold larger inhibition of Jv compared with control. Stimulation of net Cl absorption was most likely caused by inhibition of the the basolateral membrane intracellular pH-dependent Cl-HCO3 exchanger." @default.
- W2399607088 created "2016-06-24" @default.
- W2399607088 creator A5022140289 @default.
- W2399607088 creator A5065919537 @default.
- W2399607088 creator A5087660315 @default.
- W2399607088 date "1994-04-01" @default.
- W2399607088 modified "2023-10-18" @default.
- W2399607088 title "Acidification stimulates chloride and fluid absorption across frog retinal pigment epithelium" @default.
- W2399607088 cites W1582931047 @default.
- W2399607088 cites W1978949901 @default.
- W2399607088 cites W1982655809 @default.
- W2399607088 cites W1986715239 @default.
- W2399607088 cites W1997102479 @default.
- W2399607088 cites W1998050631 @default.
- W2399607088 cites W2015987866 @default.
- W2399607088 cites W2068298862 @default.
- W2399607088 cites W2073443740 @default.
- W2399607088 cites W2099824847 @default.
- W2399607088 cites W2110390774 @default.
- W2399607088 cites W2115773129 @default.
- W2399607088 cites W2160845155 @default.
- W2399607088 cites W2161463555 @default.
- W2399607088 cites W2165920470 @default.
- W2399607088 cites W2344841325 @default.
- W2399607088 doi "https://doi.org/10.1152/ajpcell.1994.266.4.c946" @default.
- W2399607088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8178967" @default.
- W2399607088 hasPublicationYear "1994" @default.
- W2399607088 type Work @default.
- W2399607088 sameAs 2399607088 @default.
- W2399607088 citedByCount "36" @default.
- W2399607088 countsByYear W23996070882013 @default.
- W2399607088 countsByYear W23996070882016 @default.
- W2399607088 countsByYear W23996070882017 @default.
- W2399607088 countsByYear W23996070882018 @default.
- W2399607088 countsByYear W23996070882019 @default.
- W2399607088 countsByYear W23996070882020 @default.
- W2399607088 countsByYear W23996070882023 @default.
- W2399607088 crossrefType "journal-article" @default.
- W2399607088 hasAuthorship W2399607088A5022140289 @default.
- W2399607088 hasAuthorship W2399607088A5065919537 @default.
- W2399607088 hasAuthorship W2399607088A5087660315 @default.
- W2399607088 hasConcept C125287762 @default.
- W2399607088 hasConcept C12554922 @default.
- W2399607088 hasConcept C134018914 @default.
- W2399607088 hasConcept C159985019 @default.
- W2399607088 hasConcept C185592680 @default.
- W2399607088 hasConcept C192562407 @default.
- W2399607088 hasConcept C2776020765 @default.
- W2399607088 hasConcept C2778024200 @default.
- W2399607088 hasConcept C2778212192 @default.
- W2399607088 hasConcept C2779533339 @default.
- W2399607088 hasConcept C2780827179 @default.
- W2399607088 hasConcept C41625074 @default.
- W2399607088 hasConcept C43617362 @default.
- W2399607088 hasConcept C55493867 @default.
- W2399607088 hasConcept C86803240 @default.
- W2399607088 hasConcept C99975950 @default.
- W2399607088 hasConceptScore W2399607088C125287762 @default.
- W2399607088 hasConceptScore W2399607088C12554922 @default.
- W2399607088 hasConceptScore W2399607088C134018914 @default.
- W2399607088 hasConceptScore W2399607088C159985019 @default.
- W2399607088 hasConceptScore W2399607088C185592680 @default.
- W2399607088 hasConceptScore W2399607088C192562407 @default.
- W2399607088 hasConceptScore W2399607088C2776020765 @default.
- W2399607088 hasConceptScore W2399607088C2778024200 @default.
- W2399607088 hasConceptScore W2399607088C2778212192 @default.
- W2399607088 hasConceptScore W2399607088C2779533339 @default.
- W2399607088 hasConceptScore W2399607088C2780827179 @default.
- W2399607088 hasConceptScore W2399607088C41625074 @default.
- W2399607088 hasConceptScore W2399607088C43617362 @default.
- W2399607088 hasConceptScore W2399607088C55493867 @default.
- W2399607088 hasConceptScore W2399607088C86803240 @default.
- W2399607088 hasConceptScore W2399607088C99975950 @default.
- W2399607088 hasIssue "4" @default.
- W2399607088 hasLocation W23996070881 @default.
- W2399607088 hasLocation W23996070882 @default.
- W2399607088 hasOpenAccess W2399607088 @default.
- W2399607088 hasPrimaryLocation W23996070881 @default.
- W2399607088 hasRelatedWork W193667007 @default.
- W2399607088 hasRelatedWork W2030292497 @default.
- W2399607088 hasRelatedWork W2037099586 @default.
- W2399607088 hasRelatedWork W2061877278 @default.
- W2399607088 hasRelatedWork W2063342945 @default.
- W2399607088 hasRelatedWork W2094407362 @default.
- W2399607088 hasRelatedWork W2117252154 @default.
- W2399607088 hasRelatedWork W2166705531 @default.
- W2399607088 hasRelatedWork W2399607088 @default.
- W2399607088 hasRelatedWork W95909497 @default.
- W2399607088 hasVolume "266" @default.
- W2399607088 isParatext "false" @default.
- W2399607088 isRetracted "false" @default.
- W2399607088 magId "2399607088" @default.
- W2399607088 workType "article" @default.