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- W2399644778 startingPage "C1908" @default.
- W2399644778 abstract "Effects of the reactive disulfides, 2,2'- and 4,4'-dithiodipyridine, on single cardiac ryanodine receptor (RyR) ion channels incorporated into lipid bilayers are reported. RyRs are activated within minutes of addition of the reactive disulfides (10(-7) to 10(-3) M) with an irreversible loss of channel activity after the activation at concentrations > or = 10(-4) M. This activation, followed by loss of activity, is seen over a wide range of cytoplasmic (cis) Ca2+ concentration between 10(-9) and 2 x 10(-2) M and occurs more rapidly with higher reactive disulfide concentrations or when RyRs are initially active at 10(-5) or 10(-3) M Ca2+. The reactive disulfides increase the channel open probability by introducing long components into the open time distributions, increasing the mean channel open time by up to 50-fold. Closed time distributions are not altered by the sulfhydryl reagents. The effects of the reactive disulfides are prevented by the reducing agents dithiothreitol and glutathione (1–10 mM). The results suggest that cysteine residues on the RyR complex can regulate the ion channel gating mechanisms." @default.
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- W2399644778 date "1997-06-01" @default.
- W2399644778 modified "2023-10-18" @default.
- W2399644778 title "Actions of sulfhydryl reagents on single ryanodine receptor Ca(2+)-release channels from sheep myocardium" @default.
- W2399644778 doi "https://doi.org/10.1152/ajpcell.1997.272.6.c1908" @default.
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