FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399648350> ?p ?o ?g. }

• W2399648350 endingPage "11" @default.
• W2399648350 startingPage "11" @default.
• W2399648350 abstract "Oral fluid matrix metalloproteinase (MMP)-8 as a diagnostic tool in chronic periodontitis Patricia Hernández-Ríos,1 Marcela Hernández,2,3 Mauricio Garrido,1 Taina Tervahartiala,4 Jussi M Leppilahti,4 Heidi Kuula,4 Anna Maria Heikkinen,4 Päivi Mäntylä,4 Nilminie Rathnayake,5 Solomon Nwhator,6 Timo Sorsa4,5 1Department of Conservative Dentistry, 2Department of Pathology and Oral Medicine, 3Laboratory of Periodontal Biology, Department of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago, Chile; 4Department of Oral and Maxillofacial Diseases, Institute of Dentistry, Helsinki University and Helsinki University Central Hospital, Helsinki, Finland; 5Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden; 6Department of Preventive and Community Dentistry, Faculty of Dentistry, College of Health Sciences, Obafemi Awolowo University, Ife, Nigeria Abstract: Periodontal diseases that affect the marginal and apical periodontium result from the interaction between bacterial biofilm and the host response. Oral fluid biomarkers might aid clinical diagnosis. Matrix metalloproteinases (MMPs) are a family of 24 proteases that act in physiological and pathological conditions. They can degrade almost all extracellular matrix constituents and regulate inflammatory processes. They are mainly inhibited by tissue inhibitors of metalloproteinases. The aim of this study was to perform a current literature review with a special reference on the diagnostic and clinical utility of oral fluid MMPs, especially MMP-8, and their inhibitors in periodontal and oral diseases. MMP-8 is the main collagenolytic MMP detected in oral fluids, such as saliva, oral mouthrinse, gingival crevicular fluid, and peri-implant fluid. MMP-8, and potentially MMP-9, in oral fluids represent strong biomarker candidates associated especially with periodontal disease diagnosis, severity, progression, and follow-up. Additionally, they show diagnostic potential for systemic conditions, such as pregnancy, myocardial infarction, and smoking. A commercially available mouthrinse, active MMP-8 chair-side/point-of-care lateral flow immunoassay, shows enough sensitivity and specificity to detect clinical signs of periodontitis. The current literature supports that high MMP-8 levels reflect the loss of periodontal supporting tissues rather than inflammation, representing a potentially useful side-diagnostic point-of-care oral disease biomarker, especially in periodontal diseases. Keywords: gingival crevicular fluid, saliva, biomarkers" @default.
• W2399648350 created "2016-06-24" @default.
• W2399648350 creator A5000905280 @default.
• W2399648350 creator A5005247667 @default.
• W2399648350 creator A5007157502 @default.
• W2399648350 creator A5008618005 @default.
• W2399648350 creator A5033826898 @default.
• W2399648350 creator A5045455955 @default.
• W2399648350 creator A5045826730 @default.
• W2399648350 creator A5049084376 @default.
• W2399648350 creator A5057611122 @default.
• W2399648350 creator A5065156977 @default.
• W2399648350 creator A5078706296 @default.
• W2399648350 date "2016-05-01" @default.
• W2399648350 modified "2023-10-17" @default.
• W2399648350 title "Oral fluid matrix metalloproteinase (MMP)-8 as a diagnostic tool in chronic periodontitis" @default.
• W2399648350 cites W1491001272 @default.
• W2399648350 cites W1571233991 @default.
• W2399648350 cites W1670999997 @default.
• W2399648350 cites W1826204675 @default.
• W2399648350 cites W1891754433 @default.
• W2399648350 cites W1955836474 @default.
• W2399648350 cites W1964163285 @default.
• W2399648350 cites W1971641879 @default.
• W2399648350 cites W1975207466 @default.
• W2399648350 cites W1977807825 @default.
• W2399648350 cites W1978106590 @default.
• W2399648350 cites W1979288174 @default.
• W2399648350 cites W1984896968 @default.
• W2399648350 cites W1990858735 @default.
• W2399648350 cites W1996726306 @default.
• W2399648350 cites W1998645118 @default.
• W2399648350 cites W1999180967 @default.
• W2399648350 cites W2005334224 @default.
• W2399648350 cites W2009021998 @default.
• W2399648350 cites W2009212230 @default.
• W2399648350 cites W2011553184 @default.
• W2399648350 cites W2011705160 @default.
• W2399648350 cites W2016720337 @default.
• W2399648350 cites W2024720149 @default.
• W2399648350 cites W2026656004 @default.
• W2399648350 cites W2029701663 @default.
• W2399648350 cites W2036895649 @default.
• W2399648350 cites W2039095330 @default.
• W2399648350 cites W2041873655 @default.
• W2399648350 cites W2045399305 @default.
• W2399648350 cites W2050390830 @default.
• W2399648350 cites W2058365833 @default.
• W2399648350 cites W2063609459 @default.
• W2399648350 cites W2063938833 @default.
• W2399648350 cites W2072960955 @default.
• W2399648350 cites W2073971623 @default.
• W2399648350 cites W2079935290 @default.
• W2399648350 cites W2084107384 @default.
• W2399648350 cites W2091663966 @default.
• W2399648350 cites W2093424872 @default.
• W2399648350 cites W2101722050 @default.
• W2399648350 cites W2102027550 @default.
• W2399648350 cites W2102869731 @default.
• W2399648350 cites W2103868159 @default.
• W2399648350 cites W2107885080 @default.
• W2399648350 cites W2108610361 @default.
• W2399648350 cites W2108931019 @default.
• W2399648350 cites W2109341430 @default.
• W2399648350 cites W2110649727 @default.
• W2399648350 cites W2110770890 @default.
• W2399648350 cites W2111587435 @default.
• W2399648350 cites W2113881801 @default.
• W2399648350 cites W2114223799 @default.
• W2399648350 cites W2118710484 @default.
• W2399648350 cites W2120581294 @default.
• W2399648350 cites W2121991787 @default.
• W2399648350 cites W2122704451 @default.
• W2399648350 cites W2122772473 @default.
• W2399648350 cites W2132290892 @default.
• W2399648350 cites W2134559280 @default.
• W2399648350 cites W2138827736 @default.
• W2399648350 cites W2144259342 @default.
• W2399648350 cites W2146967803 @default.
• W2399648350 cites W2151445204 @default.
• W2399648350 cites W2154102213 @default.
• W2399648350 cites W2156301058 @default.
• W2399648350 cites W2158345683 @default.
• W2399648350 cites W2162097910 @default.
• W2399648350 cites W2164926125 @default.
• W2399648350 cites W2165362580 @default.
• W2399648350 cites W2167436419 @default.
• W2399648350 cites W2169633121 @default.
• W2399648350 cites W2172283952 @default.
• W2399648350 cites W2181366448 @default.
• W2399648350 cites W2191274915 @default.
• W2399648350 cites W2197996134 @default.
• W2399648350 cites W2262950953 @default.
• W2399648350 cites W2328367064 @default.
• W2399648350 cites W2400544626 @default.
• W2399648350 cites W2443753783 @default.
• W2399648350 doi "https://doi.org/10.2147/mnm.s89245" @default.
• W2399648350 hasPublicationYear "2016" @default.

• next