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• W2399668734 endingPage "1415" @default.
• W2399668734 startingPage "1412" @default.
• W2399668734 abstract "The Toll-like receptor 2 ligand Pam3CysSer is of particular interest for the construction synthetic vaccines because of its ability to stimulate of the innate immune system. Such vaccines usually comprise Pam3CysSer with the natural R-configuration at the glycerol 2-position. Pam3CysSer peptide vaccines with natural configuration have been shown to be more efficient than the corresponding R/S diastereomers. In order to clarify whether the effect of the configuration of Pam3Cys on the immune response also applies to glycopeptide vaccines, MUC1 glycopeptide–lipopeptide vaccines bearing either R- or R/S-configured Pam3CysSerLys4 were compared for their immunological effects. In order to find out whether glycosylated MUC1 tandem repeat domains comprise not only B-cell epitopes but also T-cell epitopes, two-component vaccines containing the Pam3CysSerLys4 lipopeptide and MUC1 glycopeptides with various glycosylation patterns were synthesized, and their immune reactions in mice were studied." @default.
• W2399668734 created "2016-06-24" @default.
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• W2399668734 date "2016-06-15" @default.
• W2399668734 modified "2023-10-16" @default.
• W2399668734 title "Synthetic MUC1 Antitumor Vaccine Candidates with Varied Glycosylation Pattern Bearing<i>R/S</i>-configured Pam₃CysSerLys₄" @default.
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• W2399668734 doi "https://doi.org/10.1002/cbic.201600206" @default.
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• W2399668734 hasPublicationYear "2016" @default.
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