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- W2399681446 abstract "From an hepatocarcinoma cell line (LFCL.2A), unable to grow in a culture medium in which methionine was replaced by L-homocysteine, we had previously isolated revertant clones presenting a low growth rate, a loss of tumorigenicity and an inhibition of transcription of three oncogenes: c-Ki-ras, c-Ha-ras and c-myc. Here we showed that long-term deprivation of methionine led to a depletion of spermine, while putrescine and spermidine contents remained unchanged. When the revertant cells were shifted in a medium containing methionine, the oncogene transcription (except the p53 gene) started very rapidly in parallel with an increase in the putrescine content. By contrast, spermidine and spermine contents decreased during the first hours but were not significantly different from control values after numerous subcultures in methionine-containing medium." @default.
- W2399681446 created "2016-06-24" @default.
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- W2399681446 date "1993-03-01" @default.
- W2399681446 modified "2023-09-25" @default.
- W2399681446 title "Polyamine content and oncogene expression in hepatoma cells in culture during methionine deprivation and refeeding." @default.
- W2399681446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8390803" @default.
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