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• W2399683358 abstract "Interneuron-based cell transplantation is a powerful method to modify network function in a variety of neurological disorders, including epilepsy. Whether new interneurons integrate into native neural networks in a subtype-specific manner is not well understood, and the therapeutic mechanisms underlying interneuron-based cell therapy, including the role of synaptic inhibition, are debated. In this study, we tested subtype-specific integration of transplanted interneurons using acute cortical brain slices and visualized patch-clamp recordings to measure excitatory synaptic inputs, intrinsic properties, and inhibitory synaptic outputs. Fluorescently labeled progenitor cells from the embryonic medial ganglionic eminence (MGE) were used for transplantation. At 5 wk after transplantation, MGE-derived parvalbumin-positive (PV+) interneurons received excitatory synaptic inputs, exhibited mature interneuron firing properties, and made functional synaptic inhibitory connections to native pyramidal cells that were comparable to those of native PV+ interneurons. These findings demonstrate that MGE-derived PV+ interneurons functionally integrate into subtype-appropriate physiological niches within host networks following transplantation." @default.
• W2399683358 created "2016-06-24" @default.
• W2399683358 creator A5000296959 @default.
• W2399683358 creator A5073580285 @default.
• W2399683358 date "2016-08-01" @default.
• W2399683358 modified "2023-10-08" @default.
• W2399683358 title "Synaptic integration of transplanted interneuron progenitor cells into native cortical networks" @default.
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• W2399683358 doi "https://doi.org/10.1152/jn.00321.2016" @default.
• W2399683358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4978788" @default.
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