Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399691007> ?p ?o ?g. }
- W2399691007 endingPage "3694" @default.
- W2399691007 startingPage "3686" @default.
- W2399691007 abstract "Abstract Two human melanoma cell lines were transduced with the human interleukin (IL)-7 and IL-2 genes using retroviral-mediated gene transfer. Stable, high-level cytokine expression was achieved. The in vitro growth of transduced tumors was unaltered. Neither of the IL-2- transduced melanoma cell lines grew in athymic mice, whereas one IL-7- transduced melanoma line showed retarded in vivo growth. This is consistent with animal studies suggesting a predominantly T-cell response to IL-7-transduced tumors and a more nonspecific response to IL-2-transduced tumors. Both IL-7- and IL-2-transduced melanoma cell lines could induce cytotoxic lymphocytes in mixed lymphocyte-tumor cultures. The expression of putative melanoma antigens (MAGE)-1 and MAGE-3 was unaltered by cytokine transduction. In one cell line, IL-7 transduction resulted in a marked inhibition of the immunosuppressive peptide transforming growth factor (TGF)beta 1. The results allow a comparison of immunobiologic properties of IL-7- and IL-2-transduced human melanoma cell lines in consideration of their use in genetically engineered tumor vaccines. IL-7 transduction results in stable cytokine expression and phenotypic alterations that appear to be favorable for enhanced immunogenicity and it deserves clinical testing." @default.
- W2399691007 created "2016-06-24" @default.
- W2399691007 creator A5000871461 @default.
- W2399691007 creator A5004793531 @default.
- W2399691007 creator A5013266227 @default.
- W2399691007 creator A5013787984 @default.
- W2399691007 creator A5035282690 @default.
- W2399691007 creator A5039693749 @default.
- W2399691007 creator A5049519331 @default.
- W2399691007 creator A5079021288 @default.
- W2399691007 creator A5082865912 @default.
- W2399691007 creator A5083903886 @default.
- W2399691007 date "1993-12-15" @default.
- W2399691007 modified "2023-09-28" @default.
- W2399691007 title "Transduction of human melanoma cell lines with the human interleukin-7 gene using retroviral-mediated gene transfer: comparison of immunologic properties with interleukin-2" @default.
- W2399691007 cites W1480944492 @default.
- W2399691007 cites W1486196153 @default.
- W2399691007 cites W1487231197 @default.
- W2399691007 cites W1506739623 @default.
- W2399691007 cites W1532477433 @default.
- W2399691007 cites W1536953298 @default.
- W2399691007 cites W1553667428 @default.
- W2399691007 cites W1896210612 @default.
- W2399691007 cites W1907188220 @default.
- W2399691007 cites W1965130012 @default.
- W2399691007 cites W1969733048 @default.
- W2399691007 cites W1973705988 @default.
- W2399691007 cites W1985981664 @default.
- W2399691007 cites W1988637781 @default.
- W2399691007 cites W1988638940 @default.
- W2399691007 cites W1990668606 @default.
- W2399691007 cites W2002323372 @default.
- W2399691007 cites W2003773538 @default.
- W2399691007 cites W2006662011 @default.
- W2399691007 cites W2006987944 @default.
- W2399691007 cites W2007910608 @default.
- W2399691007 cites W2009629220 @default.
- W2399691007 cites W2015866244 @default.
- W2399691007 cites W2016784633 @default.
- W2399691007 cites W2025203327 @default.
- W2399691007 cites W2044068003 @default.
- W2399691007 cites W2044253068 @default.
- W2399691007 cites W2057091891 @default.
- W2399691007 cites W2071122827 @default.
- W2399691007 cites W2078454529 @default.
- W2399691007 cites W2087070363 @default.
- W2399691007 cites W2087272945 @default.
- W2399691007 cites W2091711233 @default.
- W2399691007 cites W2093315439 @default.
- W2399691007 cites W2096025900 @default.
- W2399691007 cites W2096982903 @default.
- W2399691007 cites W2127563925 @default.
- W2399691007 cites W2140330161 @default.
- W2399691007 cites W2140888976 @default.
- W2399691007 cites W2148368831 @default.
- W2399691007 cites W2153479658 @default.
- W2399691007 cites W2161530231 @default.
- W2399691007 cites W2168251609 @default.
- W2399691007 cites W2326245275 @default.
- W2399691007 cites W2403912786 @default.
- W2399691007 cites W2407989278 @default.
- W2399691007 cites W2415906075 @default.
- W2399691007 cites W2441099112 @default.
- W2399691007 doi "https://doi.org/10.1182/blood.v82.12.3686.3686" @default.
- W2399691007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8260705" @default.
- W2399691007 hasPublicationYear "1993" @default.
- W2399691007 type Work @default.
- W2399691007 sameAs 2399691007 @default.
- W2399691007 citedByCount "43" @default.
- W2399691007 countsByYear W23996910072014 @default.
- W2399691007 countsByYear W23996910072019 @default.
- W2399691007 countsByYear W23996910072020 @default.
- W2399691007 countsByYear W23996910072021 @default.
- W2399691007 crossrefType "journal-article" @default.
- W2399691007 hasAuthorship W2399691007A5000871461 @default.
- W2399691007 hasAuthorship W2399691007A5004793531 @default.
- W2399691007 hasAuthorship W2399691007A5013266227 @default.
- W2399691007 hasAuthorship W2399691007A5013787984 @default.
- W2399691007 hasAuthorship W2399691007A5035282690 @default.
- W2399691007 hasAuthorship W2399691007A5039693749 @default.
- W2399691007 hasAuthorship W2399691007A5049519331 @default.
- W2399691007 hasAuthorship W2399691007A5079021288 @default.
- W2399691007 hasAuthorship W2399691007A5082865912 @default.
- W2399691007 hasAuthorship W2399691007A5083903886 @default.
- W2399691007 hasBestOaLocation W23996910071 @default.
- W2399691007 hasConcept C104317684 @default.
- W2399691007 hasConcept C111599444 @default.
- W2399691007 hasConcept C15152581 @default.
- W2399691007 hasConcept C153911025 @default.
- W2399691007 hasConcept C154317977 @default.
- W2399691007 hasConcept C191732599 @default.
- W2399691007 hasConcept C202751555 @default.
- W2399691007 hasConcept C203014093 @default.
- W2399691007 hasConcept C2777371288 @default.
- W2399691007 hasConcept C2777658100 @default.
- W2399691007 hasConcept C2778690821 @default.
- W2399691007 hasConcept C2780868878 @default.
- W2399691007 hasConcept C2908885563 @default.