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- W2399691958 abstract "The ability to insert a gene into hematopoietic stem cells and achieve lineage specific expression of the transferred gene within hematopoietic organs following bone marrow transplantation would create the potential to effectively treat many genetic and acquired diseases. The use of retroviral vectors to achieve this purpose has been investigated extensively in animal models and most recently, in humans. In the murine model, about 20-30% of repopulating stem cells can be genetically modified with a retroviral vector. Peripheral blood stem cells, mobilized by cytokine administration in splenectomized animals, are readily transduced and are capable of long-term reconstitution of transplant recipients with genetically modified cells. Similar protocols have been utilized to transduce highly purified stem cells from rhesus monkeys. Although long-term repopulation with cells that persistently express the transferred gene has been achieved, the frequency of cells containing the vector genome is only about 1-2%. Genetic marking of human bone marrow and peripheral blood cells has been utilized to investigate their potential for contributing to long-term reconstitution following autologous transplantation. Future work will focus on improving gene transfer efficiencies for specific therapeutic applications." @default.
- W2399691958 created "2016-06-24" @default.
- W2399691958 creator A5057387604 @default.
- W2399691958 date "2000-06-15" @default.
- W2399691958 modified "2023-10-16" @default.
- W2399691958 title "Gene Transfer into Hematopoietic Stem Cells" @default.
- W2399691958 cites W193879736 @default.
- W2399691958 doi "https://doi.org/10.1201/9781420002126-31" @default.
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