Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399765150> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2399765150 endingPage "5" @default.
- W2399765150 startingPage "301" @default.
- W2399765150 abstract "Electric stimulation and drug-induced ventricular fibrillation (VF), monophasic action potentials (MAP), and triggered activity were studied before and after administration of tetrahydroberberine (THB) in rabbits, rats or guinea pigs. At doses of 5, 10, and 20 mg.kg-1, i.v. THB increased the ventricular fibrillation threshold, and the BaCl2-induced VF was also prevented or terminated by THB in rabbits. Centrogenic VF induced by icv aconitine in rats was inhibited by pretreatment with THB in a dose-dependent manner, whereas VF induced by iv ouabain in guinea pig was inhibited to a lesser degree. For MAP, the duration at 90% repolarization (MAPD90) was prolonged remarkably, whereas the MAPD20, the MAP amplitude, and the maximal velocity of phase 0 were shortened or decreased slightly. The amplitudes of early afterdepolarization produced by cesium chloride (CsCl) were attenuated, while the cumulative threshold doses of CsCl for sustained ventricular tachycardia were elevated by THB. These results indicated that THB had an potent antifibrillatory effect, which might be attributed to its blockade of potassium, calcium, and sodium currents." @default.
- W2399765150 created "2016-06-24" @default.
- W2399765150 creator A5072566910 @default.
- W2399765150 creator A5085342011 @default.
- W2399765150 date "1993-07-01" @default.
- W2399765150 modified "2023-09-23" @default.
- W2399765150 title "Antifibrillatory effect of tetrahydroberberine." @default.
- W2399765150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8249620" @default.
- W2399765150 hasPublicationYear "1993" @default.
- W2399765150 type Work @default.
- W2399765150 sameAs 2399765150 @default.
- W2399765150 citedByCount "3" @default.
- W2399765150 crossrefType "journal-article" @default.
- W2399765150 hasAuthorship W2399765150A5072566910 @default.
- W2399765150 hasAuthorship W2399765150A5085342011 @default.
- W2399765150 hasConcept C126322002 @default.
- W2399765150 hasConcept C134018914 @default.
- W2399765150 hasConcept C146403970 @default.
- W2399765150 hasConcept C155730078 @default.
- W2399765150 hasConcept C178790620 @default.
- W2399765150 hasConcept C185263204 @default.
- W2399765150 hasConcept C185592680 @default.
- W2399765150 hasConcept C24998067 @default.
- W2399765150 hasConcept C2776331378 @default.
- W2399765150 hasConcept C2777356233 @default.
- W2399765150 hasConcept C2777547430 @default.
- W2399765150 hasConcept C2778815084 @default.
- W2399765150 hasConcept C2779133857 @default.
- W2399765150 hasConcept C2779161974 @default.
- W2399765150 hasConcept C2781005686 @default.
- W2399765150 hasConcept C517785266 @default.
- W2399765150 hasConcept C537181965 @default.
- W2399765150 hasConcept C71924100 @default.
- W2399765150 hasConcept C98274493 @default.
- W2399765150 hasConceptScore W2399765150C126322002 @default.
- W2399765150 hasConceptScore W2399765150C134018914 @default.
- W2399765150 hasConceptScore W2399765150C146403970 @default.
- W2399765150 hasConceptScore W2399765150C155730078 @default.
- W2399765150 hasConceptScore W2399765150C178790620 @default.
- W2399765150 hasConceptScore W2399765150C185263204 @default.
- W2399765150 hasConceptScore W2399765150C185592680 @default.
- W2399765150 hasConceptScore W2399765150C24998067 @default.
- W2399765150 hasConceptScore W2399765150C2776331378 @default.
- W2399765150 hasConceptScore W2399765150C2777356233 @default.
- W2399765150 hasConceptScore W2399765150C2777547430 @default.
- W2399765150 hasConceptScore W2399765150C2778815084 @default.
- W2399765150 hasConceptScore W2399765150C2779133857 @default.
- W2399765150 hasConceptScore W2399765150C2779161974 @default.
- W2399765150 hasConceptScore W2399765150C2781005686 @default.
- W2399765150 hasConceptScore W2399765150C517785266 @default.
- W2399765150 hasConceptScore W2399765150C537181965 @default.
- W2399765150 hasConceptScore W2399765150C71924100 @default.
- W2399765150 hasConceptScore W2399765150C98274493 @default.
- W2399765150 hasIssue "4" @default.
- W2399765150 hasLocation W23997651501 @default.
- W2399765150 hasOpenAccess W2399765150 @default.
- W2399765150 hasPrimaryLocation W23997651501 @default.
- W2399765150 hasRelatedWork W2292632447 @default.
- W2399765150 hasRelatedWork W2348592916 @default.
- W2399765150 hasRelatedWork W2357271016 @default.
- W2399765150 hasRelatedWork W2362857642 @default.
- W2399765150 hasRelatedWork W2365847000 @default.
- W2399765150 hasRelatedWork W2366080072 @default.
- W2399765150 hasRelatedWork W2375535704 @default.
- W2399765150 hasRelatedWork W2386242562 @default.
- W2399765150 hasRelatedWork W2393017609 @default.
- W2399765150 hasRelatedWork W2399765150 @default.
- W2399765150 hasVolume "14" @default.
- W2399765150 isParatext "false" @default.
- W2399765150 isRetracted "false" @default.
- W2399765150 magId "2399765150" @default.
- W2399765150 workType "article" @default.