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• W2399833957 abstract "Protein kinase C betaII (PKCbII) represents a novel potential target for anticancer therapies in breast cancer. In order to identify patient subgroups which might benefit from PKC-targeting therapies, we investigated the expression of PKCbII in human breast cancer cell lines and in a tissue microarray (TMA). We first screened breast cancer cell line representatives of breast cancer subtypes for PKCbII expression at the mRNA and at the protein levels. We analyzed a TMA comprising of tumors from 438 patients with a median followup of 15.4 years for PKCbII expression by immunohistochemistry along with other prognostic factors in breast cancer. Among a panel of human breast cancer cell lines, only MDA-MB-436, a triple negative basal cell line, showed overexpression for PKCbII both at the mRNA and at the protein levels. In breast cancer patients, cytoplasmic expression of PKCbII correlated positively with human epidermal growth factor receptor-2 (HER-2; P = 0.01) and Ki-67 (P = 0.016), while nuclear PKCbII correlated positively with estrogen receptor (ER; P = 0.016). The positive correlation of CK5/6 with cyto- plasmic PKCbII (P = 0.033) lost statistical significance after adjusting for multiple comparisons (P = 0.198). Cytoplasmic PKCbII did not correlate with cyclooxygenase (COX-2; P = 0.925) and vascular endothelial growth factor (P = 1). There was no significant association between PKCbII staining and overall survival. Cytoplasmic PKCbII correlates with HER-2 and Ki-67, while nuclear PKCbII correlates with ER in breast cancer. Our study suggests the necessity for assessing the subcellular localization of PKCbII in breast cancer subtypes when evaluating the possible effectiveness of PKCbII-targeting agents." @default.
• W2399833957 created "2016-06-24" @default.
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• W2399833957 date "2010-01-01" @default.
• W2399833957 modified "2023-09-24" @default.
• W2399833957 title "Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes" @default.
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