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- W2399845563 abstract "Objective To investigate the expression and distribution of mast cell tryptase (MCT) in scar, and to discuss the different MCT gene expression in keloid, hypertrophic scar and normal skin. Methods 20 samples of keloid, 20 samples of hypertrophic scar and 20 samples of normal skin were collected. The distribution of MCT was investigated by immunofluorescence histochemistry, and the MCT mRNA expression was detected by Relative Quantification real-time fluorescent PCR. Results MCT gene was mainly located in the collagen fiber bundles of the scar, especially in the superficial layer of scar. MCT mRNA expression was significantly higher in keloid than that in hypertrophic scar and normal skin (P < 0. 01) . Averagely, the MCT gene expression in keloid was 2. 5 times and S. 4 times of that in hypertrophic scar and normal skin. Conclusions MCT gene may play a role in the pathogenesis of scar.Key words: Keloids; Hypertrophic scar; Mast cell tryptase" @default.
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- W2399845563 date "2010-03-01" @default.
- W2399845563 modified "2023-10-08" @default.
- W2399845563 title "Expression of mast cell tryptase in scar" @default.
- W2399845563 doi "https://doi.org/10.3760/cma.j.issn.1009-4598.2010.02.014" @default.
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