Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399924580> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2399924580 endingPage "8" @default.
- W2399924580 startingPage "33" @default.
- W2399924580 abstract "Atracurium besylate is a highly selective nondepolarizing neuromuscular blocking agent routinely used during anesthetic procedures. The commercial presentation of this drug is a mixture of positional isomers, cis-cis, cis-trans, and trans-trans. Reversed-phase high-performance liquid chromatography has been the technique of choice for the analysis of atracurium besylate formulations at the quality control laboratory of Núcleo de Desenvolvimento Cristália (São Paulo, Brazil), a local pharmaceutical company. HPLC analysis is usually conducted under gradient elution using acetonitrile/0.1 M phosphate buffer eluent mixture as mobile phase and an octadecyl silica (ODS)-packed column. The complete elution of the three isomers takes about 1 hr. In this work, an alternative capillary electrophoresis methodology was developed. The complete resolution of all three isomers was accomplished in about 13 min (+20 kV/72 cm, 211 nm direct detection) using a 60-mM phosphate buffer solution (pH 4) containing 20 mM beta-cyclodextrin and 4 M urea. The isomer ratio was found to be 59.1% cis-cis, 35.9% cis-trans, and 5.02% trans-trans (expected ratio: 59:35:6). Laudanosine, a major metabolite of atracurium besylate, was identified in two commercially available formulations, Tracur (Núcleo de Desenvolvimento Cristália) and Tracrium (Glaxo Wellcome, S.A., Rio de Janeiro, Brazil). Its concentration increases considerably during storage of the product, even if the product is stored at low temperatures." @default.
- W2399924580 created "2016-06-24" @default.
- W2399924580 creator A5010316767 @default.
- W2399924580 creator A5026424712 @default.
- W2399924580 creator A5050625916 @default.
- W2399924580 creator A5059087773 @default.
- W2399924580 date "1999-05-18" @default.
- W2399924580 modified "2023-09-23" @default.
- W2399924580 title "Comparative evaluation of capillary electrophoresis and high-performance liquid chromatography for the separation of cis-cis, cis-trans, and trans-trans isomers of atracurium besylate." @default.
- W2399924580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10327367" @default.
- W2399924580 hasPublicationYear "1999" @default.
- W2399924580 type Work @default.
- W2399924580 sameAs 2399924580 @default.
- W2399924580 citedByCount "1" @default.
- W2399924580 countsByYear W23999245802016 @default.
- W2399924580 crossrefType "journal-article" @default.
- W2399924580 hasAuthorship W2399924580A5010316767 @default.
- W2399924580 hasAuthorship W2399924580A5026424712 @default.
- W2399924580 hasAuthorship W2399924580A5050625916 @default.
- W2399924580 hasAuthorship W2399924580A5059087773 @default.
- W2399924580 hasConcept C138268822 @default.
- W2399924580 hasConcept C154945302 @default.
- W2399924580 hasConcept C176788430 @default.
- W2399924580 hasConcept C179998833 @default.
- W2399924580 hasConcept C185592680 @default.
- W2399924580 hasConcept C202235601 @default.
- W2399924580 hasConcept C2777463227 @default.
- W2399924580 hasConcept C2900643 @default.
- W2399924580 hasConcept C41008148 @default.
- W2399924580 hasConcept C43617362 @default.
- W2399924580 hasConcept C71240020 @default.
- W2399924580 hasConcept C73826308 @default.
- W2399924580 hasConceptScore W2399924580C138268822 @default.
- W2399924580 hasConceptScore W2399924580C154945302 @default.
- W2399924580 hasConceptScore W2399924580C176788430 @default.
- W2399924580 hasConceptScore W2399924580C179998833 @default.
- W2399924580 hasConceptScore W2399924580C185592680 @default.
- W2399924580 hasConceptScore W2399924580C202235601 @default.
- W2399924580 hasConceptScore W2399924580C2777463227 @default.
- W2399924580 hasConceptScore W2399924580C2900643 @default.
- W2399924580 hasConceptScore W2399924580C41008148 @default.
- W2399924580 hasConceptScore W2399924580C43617362 @default.
- W2399924580 hasConceptScore W2399924580C71240020 @default.
- W2399924580 hasConceptScore W2399924580C73826308 @default.
- W2399924580 hasIssue "1-2" @default.
- W2399924580 hasLocation W23999245801 @default.
- W2399924580 hasOpenAccess W2399924580 @default.
- W2399924580 hasPrimaryLocation W23999245801 @default.
- W2399924580 hasRelatedWork W1606369602 @default.
- W2399924580 hasRelatedWork W1967517180 @default.
- W2399924580 hasRelatedWork W2004304270 @default.
- W2399924580 hasRelatedWork W2042123112 @default.
- W2399924580 hasRelatedWork W2054666631 @default.
- W2399924580 hasRelatedWork W2056448400 @default.
- W2399924580 hasRelatedWork W2082795425 @default.
- W2399924580 hasRelatedWork W2318868746 @default.
- W2399924580 hasRelatedWork W2354951775 @default.
- W2399924580 hasRelatedWork W2384941806 @default.
- W2399924580 hasVolume "5" @default.
- W2399924580 isParatext "false" @default.
- W2399924580 isRetracted "false" @default.
- W2399924580 magId "2399924580" @default.
- W2399924580 workType "article" @default.