Matches in SemOpenAlex for { <https://semopenalex.org/work/W2399974854> ?p ?o ?g. }
- W2399974854 abstract "Frizzled3 (Fzd3), a member of the core planar cell polarity (PCP) family in mammals, contributes to visual development by guiding axonal projections of some retinal ganglion cells. However, its other functions in the maturation of the visual system, especially the retina, remain elusive. The present study explores the role of Fzd3 in retinal development by focusing on rod bipolar cells (RBCs).Frizzled3 was conditionally removed from the retina of Isl1-Cre;Fzd3f/- mice using the Cre-loxP system. Electroretinograms (ERGs) were performed to measure the light response of retinas. Frizzled3 expression was monitored by β-galactosidase (β-gal) staining and anti-β-gal immunostaining. Immunofluorescence was used to examine cellular distribution and morphology during development, and electron microscopy was applied to visualize the dendritic invaginations of RBCs.Electroretinograms showed decreased b-wave amplitudes, and lower b- to a-wave ratios in Isl1-Cre;Fzd3f/- than in control (Isl1-Cre;Fzd3f/+) mice. In RBCs, where Fzd3 was expressed and inactivated, the planar organization, shape, and orientation of somas were disrupted. From P10, dendrites of these RBCs displayed reduced arborization with mistargeting. Furthermore, their dendritic invaginations into rod terminals were suppressed, and the density of rod ribbons in the OPL was reduced.Frizzled3 is required to shape the pattern of RBC somas and dendrites, and the structural and functional connectivity between rods and RBCs. Our results highlight novel functions for Fzd3 in regulating retinal development." @default.
- W2399974854 created "2016-06-24" @default.
- W2399974854 creator A5005434770 @default.
- W2399974854 creator A5019003619 @default.
- W2399974854 creator A5024103816 @default.
- W2399974854 creator A5048519194 @default.
- W2399974854 creator A5053322257 @default.
- W2399974854 creator A5074343111 @default.
- W2399974854 creator A5074976551 @default.
- W2399974854 creator A5078449214 @default.
- W2399974854 date "2016-05-23" @default.
- W2399974854 modified "2023-09-27" @default.
- W2399974854 title "Frizzled3Shapes the Development of Retinal Rod Bipolar Cells" @default.
- W2399974854 cites W1499437796 @default.
- W2399974854 cites W1533904168 @default.
- W2399974854 cites W1964170966 @default.
- W2399974854 cites W1966344073 @default.
- W2399974854 cites W1968100682 @default.
- W2399974854 cites W1978789471 @default.
- W2399974854 cites W1996609490 @default.
- W2399974854 cites W1996847587 @default.
- W2399974854 cites W1999352891 @default.
- W2399974854 cites W2001670860 @default.
- W2399974854 cites W2002103394 @default.
- W2399974854 cites W2012802764 @default.
- W2399974854 cites W2013846991 @default.
- W2399974854 cites W2023178886 @default.
- W2399974854 cites W2031599833 @default.
- W2399974854 cites W2040239808 @default.
- W2399974854 cites W2046297486 @default.
- W2399974854 cites W2056789333 @default.
- W2399974854 cites W2057953361 @default.
- W2399974854 cites W2058483899 @default.
- W2399974854 cites W2069660062 @default.
- W2399974854 cites W2071869299 @default.
- W2399974854 cites W2076900594 @default.
- W2399974854 cites W2078799078 @default.
- W2399974854 cites W2079086020 @default.
- W2399974854 cites W2087238430 @default.
- W2399974854 cites W2092209687 @default.
- W2399974854 cites W2098179044 @default.
- W2399974854 cites W2098342524 @default.
- W2399974854 cites W2110128463 @default.
- W2399974854 cites W2121185789 @default.
- W2399974854 cites W2147289229 @default.
- W2399974854 cites W2150471451 @default.
- W2399974854 cites W2152907543 @default.
- W2399974854 cites W2159817218 @default.
- W2399974854 cites W2168599434 @default.
- W2399974854 cites W2181885838 @default.
- W2399974854 doi "https://doi.org/10.1167/iovs.16-19281" @default.
- W2399974854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27214687" @default.
- W2399974854 hasPublicationYear "2016" @default.
- W2399974854 type Work @default.
- W2399974854 sameAs 2399974854 @default.
- W2399974854 citedByCount "7" @default.
- W2399974854 countsByYear W23999748542017 @default.
- W2399974854 countsByYear W23999748542018 @default.
- W2399974854 countsByYear W23999748542019 @default.
- W2399974854 countsByYear W23999748542021 @default.
- W2399974854 crossrefType "journal-article" @default.
- W2399974854 hasAuthorship W2399974854A5005434770 @default.
- W2399974854 hasAuthorship W2399974854A5019003619 @default.
- W2399974854 hasAuthorship W2399974854A5024103816 @default.
- W2399974854 hasAuthorship W2399974854A5048519194 @default.
- W2399974854 hasAuthorship W2399974854A5053322257 @default.
- W2399974854 hasAuthorship W2399974854A5074343111 @default.
- W2399974854 hasAuthorship W2399974854A5074976551 @default.
- W2399974854 hasAuthorship W2399974854A5078449214 @default.
- W2399974854 hasBestOaLocation W23999748541 @default.
- W2399974854 hasConcept C105702510 @default.
- W2399974854 hasConcept C169760540 @default.
- W2399974854 hasConcept C185592680 @default.
- W2399974854 hasConcept C203014093 @default.
- W2399974854 hasConcept C204232928 @default.
- W2399974854 hasConcept C2777093970 @default.
- W2399974854 hasConcept C2777624874 @default.
- W2399974854 hasConcept C2780827179 @default.
- W2399974854 hasConcept C4224716 @default.
- W2399974854 hasConcept C55493867 @default.
- W2399974854 hasConcept C86803240 @default.
- W2399974854 hasConcept C95444343 @default.
- W2399974854 hasConceptScore W2399974854C105702510 @default.
- W2399974854 hasConceptScore W2399974854C169760540 @default.
- W2399974854 hasConceptScore W2399974854C185592680 @default.
- W2399974854 hasConceptScore W2399974854C203014093 @default.
- W2399974854 hasConceptScore W2399974854C204232928 @default.
- W2399974854 hasConceptScore W2399974854C2777093970 @default.
- W2399974854 hasConceptScore W2399974854C2777624874 @default.
- W2399974854 hasConceptScore W2399974854C2780827179 @default.
- W2399974854 hasConceptScore W2399974854C4224716 @default.
- W2399974854 hasConceptScore W2399974854C55493867 @default.
- W2399974854 hasConceptScore W2399974854C86803240 @default.
- W2399974854 hasConceptScore W2399974854C95444343 @default.
- W2399974854 hasLocation W23999748541 @default.
- W2399974854 hasLocation W23999748542 @default.
- W2399974854 hasOpenAccess W2399974854 @default.
- W2399974854 hasPrimaryLocation W23999748541 @default.
- W2399974854 hasRelatedWork W1994385899 @default.
- W2399974854 hasRelatedWork W2030349544 @default.