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- W2399997888 abstract "It is tempting to speculate that Hamlet recognized the infectious etiology of peptic ulcer disease, thus presaging recent developments in modern medicine. As old microbes are resurging and new pathogens are emerging, the study of infectious causes of disease is again in the forefront of medicine. Helicobacter pylori, the elusive, acidtolerant bacteria first associated with gastritis, peptic ulcer disease, nonulcer dyspepsia and, finally, gastric cancer, serve as a paradigm for the evolution of infectious disease in modern medicine. Until recently, the pathogenesis of ulcer disease was attributed to overproduction of acid and mucosal barrier destruction as a result of stress, smoking, or dietary factors. The dogma that environmental and genetic factors predisposed individuals to the development of gastric cancer was universally accepted, and H pylori was considered to be a possible cause of gastritis.[1] Now, a few years later, H pylori is a prominent topic at conferences and in medical journals and is notorious as a cause of a multitude of gastric diseases. The search for a causal role and for further understanding of the pathogenetic properties of H pylori has spawned numerous investigations. Its role in gastric cancer has raised questions regarding the association of the bacteria with carcinogenic processes, as well as its potential role for eradication of these bacteria in cancer prevention. This revolution in medical thought the concept of a unified infectious cause of gastritis, ulcer disease, and cancer has led to a new path of progress that exemplifies the change in how human disease is approached." @default.
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- W2399997888 date "1995-11-01" @default.
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- W2399997888 title "Infections in Oncology: Gastric Cancer: An Infectious Disease?" @default.
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