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• W2400000090 abstract "Objective: The authors describe their experience with the use of intravenous s2 adrenergic (IV terbutaline) in patients admitted to a PICU with severe lower airway obstruction. Patients and methods: A retrospective study of all admissions to a PICU was conducted in Santo Antonio Hospital in Porto Alegre City (Brazil) during the winter of 1995. The files of all the patients that were treated with intravenous s2 adrenergic as a bronchodilator were selected. The analysis included length of use, initial doses, maximal doses, associated phenomena, arterial blood gases and plasma level of potassium. Results: During the three months of study 367 patients were admitted to the PICU and 38 (10.3%) used IV terbutaline. This group of patients had a mean age of 13.8 ± 12.2 months old and used IV terbutaline for a mean length of 7.24 ± 3.6 days. The initial rate of infusion was 0.55 ± 0.25 mcg/kg/min with a mean therapeutic dose of 2.45 ± 1.18 mcg/kg/min. Twelve patients (31.5%) had increase in their heart rate (over 180 bpm) that prevented increases in the infusion rate. However this was a temporary effect. The patients under 12 months of age started with low infusion rates (0.45 ± 0.22 mcg/kg/min), when compared to children over 1 year old (0.57 ± 0.3 mcg/kg/min), p < 0.01. No patient developed pathologic heart rate attributed to the drug. The serum levels of potassium decreased significantly (p < 0.01) only in the group of patients under 1 year (4.1 ± 0.7 to 3.47 ± 0.52 mEq/L), but this difference had no clinical relevance. Comments: In view of these results the authors showed that the infusion of IV terbutaline in children is safe and presents a low risk if the criteria of administration and monitoring are followed. In this manner, IV terbutaline is an excellent therapeutic option for children with severe lower airway obstruction and no response to the conventional treatment." @default.
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• W2400000090 date "1998-01-01" @default.
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• W2400000090 title "Terbutalina endovenosa em crianças * Intravenous terbutaline in children" @default.
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