Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400019105> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2400019105 endingPage "500" @default.
- W2400019105 startingPage "1489" @default.
- W2400019105 abstract "To explore the changes of exorine pancreas in the early stage after ligation of pancreatico-biliary duct (PBD) in rat, we evaluated the changes of serum amylase levels, pancreatic water content as well as the changes of subcellular distribution of cathepsin B in the acinar cells. We also evaluated the lactic dehydrogenase (LDH) discharge from dispersed acini as an index of cellular fragility and cathepsin B leakage from lysosomes as an index lysosomal fragility in vitro study as well as the protective effects of a new synthetic protease inhibitor, nafamostat mesilate (FUT 175) in this model. After ligation of PBD, the serum amylase levels and pancreatic water content, increased significantly compared with those of the control group, but returning to the normal levels at 18 hours. The redistribution of cathepsin B in acinar cells was found and both the cellular and lysosomal fragility increased significantly compared with those of the control groups, shown their peak changes at 12 hours after ligation of PBD. But continuous intravenous administration of FUT 175 (2mg/mg.hr) remarkably attenuated all the parameters. These results indicate the important roles of lysosomal enzyme and lysosomal fragility in the pathogenesis of acute pancreatic injuries in this modes, and the clinical usefulness of FUT 175 in the treatment acute pancreatitis." @default.
- W2400019105 created "2016-06-24" @default.
- W2400019105 creator A5002861397 @default.
- W2400019105 creator A5036554469 @default.
- W2400019105 creator A5057853028 @default.
- W2400019105 date "1992-12-01" @default.
- W2400019105 modified "2023-09-23" @default.
- W2400019105 title "[The cellular and lysosomal fragility of pancreatic acinar cells after ligation of pancreatico-biliary duct in the rat and the protective effects of nafamostat mesilate]." @default.
- W2400019105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1283776" @default.
- W2400019105 hasPublicationYear "1992" @default.
- W2400019105 type Work @default.
- W2400019105 sameAs 2400019105 @default.
- W2400019105 citedByCount "0" @default.
- W2400019105 crossrefType "journal-article" @default.
- W2400019105 hasAuthorship W2400019105A5002861397 @default.
- W2400019105 hasAuthorship W2400019105A5036554469 @default.
- W2400019105 hasAuthorship W2400019105A5057853028 @default.
- W2400019105 hasConcept C126322002 @default.
- W2400019105 hasConcept C134018914 @default.
- W2400019105 hasConcept C167844969 @default.
- W2400019105 hasConcept C170835558 @default.
- W2400019105 hasConcept C179437574 @default.
- W2400019105 hasConcept C181199279 @default.
- W2400019105 hasConcept C185592680 @default.
- W2400019105 hasConcept C2775967933 @default.
- W2400019105 hasConcept C2776670229 @default.
- W2400019105 hasConcept C2778764654 @default.
- W2400019105 hasConcept C2779960720 @default.
- W2400019105 hasConcept C28021979 @default.
- W2400019105 hasConcept C55493867 @default.
- W2400019105 hasConcept C71924100 @default.
- W2400019105 hasConceptScore W2400019105C126322002 @default.
- W2400019105 hasConceptScore W2400019105C134018914 @default.
- W2400019105 hasConceptScore W2400019105C167844969 @default.
- W2400019105 hasConceptScore W2400019105C170835558 @default.
- W2400019105 hasConceptScore W2400019105C179437574 @default.
- W2400019105 hasConceptScore W2400019105C181199279 @default.
- W2400019105 hasConceptScore W2400019105C185592680 @default.
- W2400019105 hasConceptScore W2400019105C2775967933 @default.
- W2400019105 hasConceptScore W2400019105C2776670229 @default.
- W2400019105 hasConceptScore W2400019105C2778764654 @default.
- W2400019105 hasConceptScore W2400019105C2779960720 @default.
- W2400019105 hasConceptScore W2400019105C28021979 @default.
- W2400019105 hasConceptScore W2400019105C55493867 @default.
- W2400019105 hasConceptScore W2400019105C71924100 @default.
- W2400019105 hasIssue "12" @default.
- W2400019105 hasLocation W24000191051 @default.
- W2400019105 hasOpenAccess W2400019105 @default.
- W2400019105 hasPrimaryLocation W24000191051 @default.
- W2400019105 hasRelatedWork W2056470449 @default.
- W2400019105 hasRelatedWork W2058562050 @default.
- W2400019105 hasRelatedWork W2080499706 @default.
- W2400019105 hasRelatedWork W2091138541 @default.
- W2400019105 hasRelatedWork W2112634777 @default.
- W2400019105 hasRelatedWork W2360587321 @default.
- W2400019105 hasRelatedWork W2368214281 @default.
- W2400019105 hasRelatedWork W2400019105 @default.
- W2400019105 hasRelatedWork W2419504297 @default.
- W2400019105 hasRelatedWork W4237425982 @default.
- W2400019105 hasVolume "93" @default.
- W2400019105 isParatext "false" @default.
- W2400019105 isRetracted "false" @default.
- W2400019105 magId "2400019105" @default.
- W2400019105 workType "article" @default.