FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400104327> ?p ?o ?g. }

• W2400104327 endingPage "12078" @default.
• W2400104327 startingPage "12071" @default.
• W2400104327 abstract "Ezrin is a protein that functions as a cross-linker between actin cytoskeleton and plasma membrane. Its clinical role in osteosarcoma is unclear. The aim of this study was to investigate, in osteosarcoma, the prognostic value of ezrin expression at biopsy and changes in expression levels after preoperative chemotherapy. Thirty-eight newly diagnosed osteosarcoma patients aged 6–23 years were included. At diagnosis, 20 patients had localized disease, the others had distant metastases. Median follow-up was 75 months (range 13–135). Ezrin expression was assessed immunohistochemically in biopsy tissue and primary tumour specimens resected after chemotherapy. The influence on survival of changes in ezrin expression after chemotherapy was analysed. Ezrin expression was significantly higher after preoperative chemotherapy and changes compared to biopsy tissue were significantly lower in patients with early progression than in patients with relapse or no further evidence of disease (p = 0.006 and p = 0.002, respectively). Similarly, ezrin expression was higher after preoperative chemotherapy and exhibited less change in expression in deceased patients compared to patients surviving more than 5 years (both p = 0.001). Ezrin expression at biopsy was significantly associated with both histopathological aggressiveness (p < 0.001) and tumour size (p = 0.037). The results of this study provide evidence that changes in overexpression of ezrin due to preoperative chemotherapy could be a useful predictive and prognostic marker in patients with osteosarcoma." @default.
• W2400104327 created "2016-06-24" @default.
• W2400104327 creator A5003403490 @default.
• W2400104327 creator A5018945720 @default.
• W2400104327 creator A5023025652 @default.
• W2400104327 creator A5040129777 @default.
• W2400104327 creator A5041689810 @default.
• W2400104327 creator A5045612752 @default.
• W2400104327 creator A5089044393 @default.
• W2400104327 date "2016-05-20" @default.
• W2400104327 modified "2023-10-02" @default.
• W2400104327 title "The clinical significance of changes in ezrin expression in osteosarcoma of children and young adults" @default.
• W2400104327 cites W1485709227 @default.
• W2400104327 cites W172065283 @default.
• W2400104327 cites W1839204217 @default.
• W2400104327 cites W1928708966 @default.
• W2400104327 cites W1969015957 @default.
• W2400104327 cites W1973882428 @default.
• W2400104327 cites W1983222825 @default.
• W2400104327 cites W1986409119 @default.
• W2400104327 cites W1988136104 @default.
• W2400104327 cites W1996543107 @default.
• W2400104327 cites W2000679132 @default.
• W2400104327 cites W2009863939 @default.
• W2400104327 cites W2012144636 @default.
• W2400104327 cites W2019287405 @default.
• W2400104327 cites W2032707867 @default.
• W2400104327 cites W2034273354 @default.
• W2400104327 cites W2051212512 @default.
• W2400104327 cites W2051360623 @default.
• W2400104327 cites W2062375074 @default.
• W2400104327 cites W2070563925 @default.
• W2400104327 cites W2072822568 @default.
• W2400104327 cites W2081228444 @default.
• W2400104327 cites W2084445246 @default.
• W2400104327 cites W2110734570 @default.
• W2400104327 cites W2112309180 @default.
• W2400104327 cites W2116686246 @default.
• W2400104327 cites W2123582482 @default.
• W2400104327 cites W2135549050 @default.
• W2400104327 cites W2141567682 @default.
• W2400104327 cites W2146140154 @default.
• W2400104327 cites W2154945604 @default.
• W2400104327 cites W2161377790 @default.
• W2400104327 cites W2162577349 @default.
• W2400104327 cites W2163821296 @default.
• W2400104327 cites W2179451082 @default.
• W2400104327 cites W2187482341 @default.
• W2400104327 cites W2329382392 @default.
• W2400104327 cites W2330748343 @default.
• W2400104327 cites W23832024 @default.
• W2400104327 cites W2469339417 @default.
• W2400104327 doi "https://doi.org/10.1007/s13277-016-5091-1" @default.
• W2400104327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27207343" @default.
• W2400104327 hasPublicationYear "2016" @default.
• W2400104327 type Work @default.
• W2400104327 sameAs 2400104327 @default.
• W2400104327 citedByCount "11" @default.
• W2400104327 countsByYear W24001043272017 @default.
• W2400104327 countsByYear W24001043272018 @default.
• W2400104327 countsByYear W24001043272019 @default.
• W2400104327 countsByYear W24001043272021 @default.
• W2400104327 countsByYear W24001043272022 @default.
• W2400104327 crossrefType "journal-article" @default.
• W2400104327 hasAuthorship W2400104327A5003403490 @default.
• W2400104327 hasAuthorship W2400104327A5018945720 @default.
• W2400104327 hasAuthorship W2400104327A5023025652 @default.
• W2400104327 hasAuthorship W2400104327A5040129777 @default.
• W2400104327 hasAuthorship W2400104327A5041689810 @default.
• W2400104327 hasAuthorship W2400104327A5045612752 @default.
• W2400104327 hasAuthorship W2400104327A5089044393 @default.
• W2400104327 hasConcept C126322002 @default.
• W2400104327 hasConcept C142669718 @default.
• W2400104327 hasConcept C142724271 @default.
• W2400104327 hasConcept C143998085 @default.
• W2400104327 hasConcept C1491633281 @default.
• W2400104327 hasConcept C2775934546 @default.
• W2400104327 hasConcept C2776694085 @default.
• W2400104327 hasConcept C2777760704 @default.
• W2400104327 hasConcept C2780246058 @default.
• W2400104327 hasConcept C54355233 @default.
• W2400104327 hasConcept C63363279 @default.
• W2400104327 hasConcept C71924100 @default.
• W2400104327 hasConcept C86803240 @default.
• W2400104327 hasConceptScore W2400104327C126322002 @default.
• W2400104327 hasConceptScore W2400104327C142669718 @default.
• W2400104327 hasConceptScore W2400104327C142724271 @default.
• W2400104327 hasConceptScore W2400104327C143998085 @default.
• W2400104327 hasConceptScore W2400104327C1491633281 @default.
• W2400104327 hasConceptScore W2400104327C2775934546 @default.
• W2400104327 hasConceptScore W2400104327C2776694085 @default.
• W2400104327 hasConceptScore W2400104327C2777760704 @default.
• W2400104327 hasConceptScore W2400104327C2780246058 @default.
• W2400104327 hasConceptScore W2400104327C54355233 @default.
• W2400104327 hasConceptScore W2400104327C63363279 @default.
• W2400104327 hasConceptScore W2400104327C71924100 @default.
• W2400104327 hasConceptScore W2400104327C86803240 @default.
• W2400104327 hasIssue "9" @default.

• next