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- W2400141172 abstract "Targeted Radionuclide Therapy (TRT) consists in killing tumour targets by using radiolabeled vectors (radiopharmaceuticals) that selectively bind to tumour cells. In a context of TRT optimization, a better determination of energy deposition within biologic material is a prerequisite to the definition of the absorbed dose-effect relationship and the improvement of future cancer treatment. This requires being able to quantitatively assess activity distribution (with the most appropriate molecular imaging technique) and perform radiation transport at the scale at which biologically relevant phenomena occur. The methodologies that should be applied and the problematic to be faced strictly depend on the scale (cell, tissue, body) of the application considered, and on the type of radiation involved (photons, electrons, alpha). This research work consisted in developing dedicated dosimetric techniques (single-scale dosimetry) capable of taking into account the peculiarity of different experimental scenarios (cellular, pre-clinical, clinical TRT)." @default.
- W2400141172 created "2016-06-24" @default.
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- W2400141172 date "2015-10-20" @default.
- W2400141172 modified "2023-09-24" @default.
- W2400141172 title "Multi-scale dosimetry for targeted radionuclide therapy optimisation" @default.
- W2400141172 hasPublicationYear "2015" @default.
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