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- W2400228311 abstract "The capacity of Salmonella minnesota R345 (Rb) binding to human peripheral blood lymphocytes allows the recovery of Rb-bound and Rb-unbound cell populations that elicit different functions. Here, we have applied this method to lymphocytes from aged individuals to evaluate the possibility that such an approach could reverse the senescence-related impaired immune responsiveness. In this regard we show that Rb binding augments either spontaneous or T-dependent plaque-forming cell generation in Rb-unbound fraction. By contrast, Rb-bound cells are enriched for lymphocytes releasing several lymphokines. This experimental approach seems to represent a useful tool to elucidate better the age-related alterations of the immune function." @default.
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- W2400228311 date "1987-01-01" @default.
- W2400228311 modified "2023-09-23" @default.
- W2400228311 title "Functional properties of Salmonella minnesota Rb-bound and Rb-unbound cell fractions in elderly donors." @default.
- W2400228311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3297381" @default.
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