FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400329507> ?p ?o ?g. }

• W2400329507 endingPage "106" @default.
• W2400329507 startingPage "102" @default.
• W2400329507 abstract "Phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling pathway performs a central role in tumorigenesis and is constitutively activated in many malignancies. As a novel dual PI3K/mTOR inhibitor currently undergoing evaluation in a phase I/II clinical trial, NVP-BEZ235 indicates a significant antitumor efficacy in diverse solid tumors, including colorectal cancer (CRC). Autophagy is a catabolic process that maintains cellular homeostasis and reduces diverse stresses through lysosomal recycling of the unnecessary and damaged cell components. This process is also observed to antagonize the antitumor efficacy of PI3K/mTOR inhibitor agents such as NVP-BEZ235, via apoptosis inhibition. In the present study, we investigated anti-proliferative and apoptosis-inducing ability of NVP-BEZ235 in SW480 cells and the crosstalk between autophagy and apoptosis in SW480 cells treated with NVP-BEZ235 in combination with an autophagy inhibitor. The results revealed that, NVP-BEZ235 effectively inhibit the growth of SW480 cells by targeting the PI3K/mTOR signaling pathway and induced apoptosis. The inhibition of autophagy with 3-methyladenine or chloroquine inhibitors in combination with NVP-BEZ235 in SW480 cells enhanced the apoptotic rate as componets to NVP-BEZ235 alone. In conclusion, the findings provide a rationale for chemotherapy targeting the PI3K/mTOR signaling pathway presenting a potential therapeutic strategy to enhance the efficacy of dual PI3K/mTOR inhibitor NVP-BEZ235 in combination with an autophagy inhibitor in CRC treatment and treatment of other tumors." @default.
• W2400329507 created "2016-06-24" @default.
• W2400329507 creator A5036818207 @default.
• W2400329507 creator A5040659765 @default.
• W2400329507 creator A5041580796 @default.
• W2400329507 creator A5048089825 @default.
• W2400329507 creator A5060378628 @default.
• W2400329507 creator A5064280954 @default.
• W2400329507 creator A5072934731 @default.
• W2400329507 creator A5090151367 @default.
• W2400329507 date "2016-05-17" @default.
• W2400329507 modified "2023-09-25" @default.
• W2400329507 title "Autophagy inhibition enhances colorectal cancer apoptosis induced by dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235" @default.
• W2400329507 cites W1523693806 @default.
• W2400329507 cites W1949584779 @default.
• W2400329507 cites W1982401280 @default.
• W2400329507 cites W1985824135 @default.
• W2400329507 cites W1988696372 @default.
• W2400329507 cites W1991692801 @default.
• W2400329507 cites W2004578932 @default.
• W2400329507 cites W2009886463 @default.
• W2400329507 cites W2010008722 @default.
• W2400329507 cites W2013036515 @default.
• W2400329507 cites W2018023891 @default.
• W2400329507 cites W2028704745 @default.
• W2400329507 cites W2054537564 @default.
• W2400329507 cites W2055107833 @default.
• W2400329507 cites W2062917145 @default.
• W2400329507 cites W2068347341 @default.
• W2400329507 cites W2078911476 @default.
• W2400329507 cites W2079355772 @default.
• W2400329507 cites W2084230370 @default.
• W2400329507 cites W2084946596 @default.
• W2400329507 cites W2085483616 @default.
• W2400329507 cites W2099373320 @default.
• W2400329507 cites W2109467838 @default.
• W2400329507 cites W2114742782 @default.
• W2400329507 cites W2114944688 @default.
• W2400329507 cites W2121813093 @default.
• W2400329507 cites W2126569401 @default.
• W2400329507 cites W2129172946 @default.
• W2400329507 cites W2131474316 @default.
• W2400329507 cites W2133093811 @default.
• W2400329507 cites W2137124072 @default.
• W2400329507 cites W2139552047 @default.
• W2400329507 cites W2146233513 @default.
• W2400329507 cites W2147169705 @default.
• W2400329507 cites W2153607816 @default.
• W2400329507 cites W2155009617 @default.
• W2400329507 cites W2157949003 @default.
• W2400329507 cites W2157983986 @default.
• W2400329507 cites W2158305336 @default.
• W2400329507 cites W2166443964 @default.
• W2400329507 cites W2169612309 @default.
• W2400329507 cites W2171095731 @default.
• W2400329507 cites W2421066065 @default.
• W2400329507 cites W4251622665 @default.
• W2400329507 doi "https://doi.org/10.3892/ol.2016.4590" @default.
• W2400329507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4906634" @default.
• W2400329507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27347108" @default.
• W2400329507 hasPublicationYear "2016" @default.
• W2400329507 type Work @default.
• W2400329507 sameAs 2400329507 @default.
• W2400329507 citedByCount "21" @default.
• W2400329507 countsByYear W24003295072017 @default.
• W2400329507 countsByYear W24003295072018 @default.
• W2400329507 countsByYear W24003295072019 @default.
• W2400329507 countsByYear W24003295072020 @default.
• W2400329507 countsByYear W24003295072021 @default.
• W2400329507 countsByYear W24003295072022 @default.
• W2400329507 countsByYear W24003295072023 @default.
• W2400329507 crossrefType "journal-article" @default.
• W2400329507 hasAuthorship W2400329507A5036818207 @default.
• W2400329507 hasAuthorship W2400329507A5040659765 @default.
• W2400329507 hasAuthorship W2400329507A5041580796 @default.
• W2400329507 hasAuthorship W2400329507A5048089825 @default.
• W2400329507 hasAuthorship W2400329507A5060378628 @default.
• W2400329507 hasAuthorship W2400329507A5064280954 @default.
• W2400329507 hasAuthorship W2400329507A5072934731 @default.
• W2400329507 hasAuthorship W2400329507A5090151367 @default.
• W2400329507 hasBestOaLocation W24003295071 @default.
• W2400329507 hasConcept C190283241 @default.
• W2400329507 hasConcept C203522944 @default.
• W2400329507 hasConcept C2777949483 @default.
• W2400329507 hasConcept C29537977 @default.
• W2400329507 hasConcept C43060935 @default.
• W2400329507 hasConcept C502942594 @default.
• W2400329507 hasConcept C55493867 @default.
• W2400329507 hasConcept C86554907 @default.
• W2400329507 hasConcept C86803240 @default.
• W2400329507 hasConcept C95444343 @default.
• W2400329507 hasConceptScore W2400329507C190283241 @default.
• W2400329507 hasConceptScore W2400329507C203522944 @default.
• W2400329507 hasConceptScore W2400329507C2777949483 @default.
• W2400329507 hasConceptScore W2400329507C29537977 @default.
• W2400329507 hasConceptScore W2400329507C43060935 @default.
• W2400329507 hasConceptScore W2400329507C502942594 @default.
• W2400329507 hasConceptScore W2400329507C55493867 @default.

• next