Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400335073> ?p ?o ?g. }
- W2400335073 abstract "Alzheimer's disease (AD) is the most common cause of dementia in those over the age of 65. While a numerous of disease-causing genes and risk factors have been identified, the exact etiological mechanisms of AD are not yet completely understood, due to the inability to test theoretical hypotheses on non-postmortem and patient-specific research systems. The use of recently developed and optimized induced pluripotent stem cells (iPSCs) technology may provide a promising platform to create reliable models, not only for better understanding the etiopathological process of AD, but also for efficient anti-AD drugs screening. More importantly, human-sourced iPSCs may also provide a beneficial tool for cell-replacement therapy against AD. Although considerable progress has been achieved, a number of key challenges still require to be addressed in iPSCs research, including the identification of robust disease phenotypes in AD modeling and the clinical availabilities of iPSCs-based cell-replacement therapy in human. In this review, we highlight recent progresses of iPSCs research and discuss the translational challenges of AD patients-derived iPSCs in disease modeling and cell-replacement therapy." @default.
- W2400335073 created "2016-06-24" @default.
- W2400335073 creator A5007172109 @default.
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- W2400335073 creator A5020088480 @default.
- W2400335073 creator A5055317204 @default.
- W2400335073 creator A5090796794 @default.
- W2400335073 date "2016-05-17" @default.
- W2400335073 modified "2023-10-15" @default.
- W2400335073 title "Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy" @default.
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