Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400372933> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2400372933 endingPage "51" @default.
- W2400372933 startingPage "1941" @default.
- W2400372933 abstract "IL-5 is produced mainly by activated Th2 and mast cells. High level of IL-5 mRNA expression is detected in c-kit- cells in the lung, spleen, stomach and small intestine in RAG2-/- mice, suggesting the IL-5 production by non-T/non-mast/non-eosinophils. The IL-5R consists of two distinct membrane proteins, IL-5Ralpha and betac. The binding of IL-5 occurs through the IL-5Ralpha, and the betac forms a high-affinity IL-5R in combination with the IL-5Ralpha and transduces signals into nuclei. Activation of Btk and Jak2 kinases, rapid tyrosine phosphorylation of betac, adaptor proteins and transcription factors STAT5; and inductions of transcription of several nuclear proto-oncogenes are essential for the IL-5 signal transduction. Transgenic mice expressing the IL-5 gene exhibit elevated levels of serum IgM, IgA and IgE, increase in numbers of B-1 cells and eosinophils, and show persistent eosinophilia. Functional analysis of the IL-5Ralpha-/- and IL-5-/- mice revealed that IL-5 plays critical roles in the homeostatic proliferation, cell survival and activation of mature B-1 cells and regulates IgA production in the mucosal tissues in response to LPS. We also found that IL-5 can induce mu to gamma1 class-switch recombination in activated B-2 cells by activating AID and Blimp-1. Taking together, IL-5 plays important roles in terminal differentiation of B-lineage cells. In humans, IL-5 preferentially acts on eosinophil precursors and mature eosinophils to prolong maturation, survival and activation. Humanized anti-IL-5 mAb treatment for asthmatic patients was shown to reduce 100% for blood eosinophils but does not deplete airway or bone marrow eosinophils. No significant changes in airway hyper-responsiveness and peak flow recordings between the anti-IL-5 and placebo-treated groups were reported. At this moment, the role of IL-5 and eosinophil in allergic inflammation remains uncertain." @default.
- W2400372933 created "2016-06-24" @default.
- W2400372933 creator A5061109700 @default.
- W2400372933 date "2004-10-01" @default.
- W2400372933 modified "2023-10-03" @default.
- W2400372933 title "[Role of interleukin-5 in immune regulation and inflammation]." @default.
- W2400372933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15500144" @default.
- W2400372933 hasPublicationYear "2004" @default.
- W2400372933 type Work @default.
- W2400372933 sameAs 2400372933 @default.
- W2400372933 citedByCount "4" @default.
- W2400372933 countsByYear W24003729332013 @default.
- W2400372933 countsByYear W24003729332015 @default.
- W2400372933 crossrefType "journal-article" @default.
- W2400372933 hasAuthorship W2400372933A5061109700 @default.
- W2400372933 hasConcept C141105273 @default.
- W2400372933 hasConcept C153911025 @default.
- W2400372933 hasConcept C159654299 @default.
- W2400372933 hasConcept C183786373 @default.
- W2400372933 hasConcept C203014093 @default.
- W2400372933 hasConcept C2776042228 @default.
- W2400372933 hasConcept C2776914184 @default.
- W2400372933 hasConcept C2777037409 @default.
- W2400372933 hasConcept C2777553839 @default.
- W2400372933 hasConcept C2779391668 @default.
- W2400372933 hasConcept C2779675166 @default.
- W2400372933 hasConcept C42362537 @default.
- W2400372933 hasConcept C62478195 @default.
- W2400372933 hasConcept C86803240 @default.
- W2400372933 hasConcept C90059517 @default.
- W2400372933 hasConcept C95444343 @default.
- W2400372933 hasConceptScore W2400372933C141105273 @default.
- W2400372933 hasConceptScore W2400372933C153911025 @default.
- W2400372933 hasConceptScore W2400372933C159654299 @default.
- W2400372933 hasConceptScore W2400372933C183786373 @default.
- W2400372933 hasConceptScore W2400372933C203014093 @default.
- W2400372933 hasConceptScore W2400372933C2776042228 @default.
- W2400372933 hasConceptScore W2400372933C2776914184 @default.
- W2400372933 hasConceptScore W2400372933C2777037409 @default.
- W2400372933 hasConceptScore W2400372933C2777553839 @default.
- W2400372933 hasConceptScore W2400372933C2779391668 @default.
- W2400372933 hasConceptScore W2400372933C2779675166 @default.
- W2400372933 hasConceptScore W2400372933C42362537 @default.
- W2400372933 hasConceptScore W2400372933C62478195 @default.
- W2400372933 hasConceptScore W2400372933C86803240 @default.
- W2400372933 hasConceptScore W2400372933C90059517 @default.
- W2400372933 hasConceptScore W2400372933C95444343 @default.
- W2400372933 hasIssue "10" @default.
- W2400372933 hasLocation W24003729331 @default.
- W2400372933 hasOpenAccess W2400372933 @default.
- W2400372933 hasPrimaryLocation W24003729331 @default.
- W2400372933 hasRelatedWork W188346040 @default.
- W2400372933 hasRelatedWork W1969512070 @default.
- W2400372933 hasRelatedWork W1993464074 @default.
- W2400372933 hasRelatedWork W2013517235 @default.
- W2400372933 hasRelatedWork W2053838441 @default.
- W2400372933 hasRelatedWork W2071586072 @default.
- W2400372933 hasRelatedWork W2088149329 @default.
- W2400372933 hasRelatedWork W2147244920 @default.
- W2400372933 hasRelatedWork W2400372933 @default.
- W2400372933 hasRelatedWork W2969035199 @default.
- W2400372933 hasVolume "62" @default.
- W2400372933 isParatext "false" @default.
- W2400372933 isRetracted "false" @default.
- W2400372933 magId "2400372933" @default.
- W2400372933 workType "article" @default.