Matches in SemOpenAlex for { <https://semopenalex.org/work/W2400382093> ?p ?o ?g. }
- W2400382093 endingPage "1339" @default.
- W2400382093 startingPage "1330" @default.
- W2400382093 abstract "The mechanism regulating the gastrointestinal epithelial barrier remains poorly understood. We herein demonstrate that Absent in melanoma-2 (AIM2) contributes to the maintenance of intestinal barrier integrity and defense against bacterial infection. AIM2-deficient mice displayed an increased susceptibility to mucosal but not systemic infection by Salmonella typhimurium, indicating a protective role for AIM2 in the gastrointestinal tract. In a Salmonella colitis model, compared with wild-type mice, AIM2(-/-) mice exhibited more severe body weight loss, intestinal damage, intestinal inflammation, and disruption of basal and activated epithelial cell turnover. In vivo and in vitro data showed that AIM2 restricted the early epithelial paracellular invasion of Salmonella and decreased epithelial permeability. The decreased epithelial barrier in AIM2(-/-) mice might be attributed to the altered expression of tight junction proteins that contribute to epithelial integrity. AIM2 promoted the expression of tight junction proteins through Akt activation. Together, these results suggest that AIM2 is required for maintaining the integrity of the epithelial barrier." @default.
- W2400382093 created "2016-06-24" @default.
- W2400382093 creator A5014454408 @default.
- W2400382093 creator A5017422077 @default.
- W2400382093 creator A5029285963 @default.
- W2400382093 creator A5038842968 @default.
- W2400382093 creator A5043264626 @default.
- W2400382093 creator A5048844719 @default.
- W2400382093 creator A5051447149 @default.
- W2400382093 creator A5051587677 @default.
- W2400382093 creator A5082033303 @default.
- W2400382093 creator A5089118944 @default.
- W2400382093 creator A5091827649 @default.
- W2400382093 date "2016-09-01" @default.
- W2400382093 modified "2023-10-06" @default.
- W2400382093 title "AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection" @default.
- W2400382093 cites W1805865584 @default.
- W2400382093 cites W1973288627 @default.
- W2400382093 cites W1974690862 @default.
- W2400382093 cites W1977475597 @default.
- W2400382093 cites W1984632540 @default.
- W2400382093 cites W1988725062 @default.
- W2400382093 cites W1993876075 @default.
- W2400382093 cites W1997763763 @default.
- W2400382093 cites W2009351870 @default.
- W2400382093 cites W2014494685 @default.
- W2400382093 cites W2020120915 @default.
- W2400382093 cites W2025065287 @default.
- W2400382093 cites W2030855312 @default.
- W2400382093 cites W2031502524 @default.
- W2400382093 cites W2031743395 @default.
- W2400382093 cites W2031967942 @default.
- W2400382093 cites W2037036600 @default.
- W2400382093 cites W2042816890 @default.
- W2400382093 cites W2049269681 @default.
- W2400382093 cites W2053260332 @default.
- W2400382093 cites W2063809138 @default.
- W2400382093 cites W2064372156 @default.
- W2400382093 cites W2070413937 @default.
- W2400382093 cites W2072041559 @default.
- W2400382093 cites W2073423435 @default.
- W2400382093 cites W2073647905 @default.
- W2400382093 cites W2077038301 @default.
- W2400382093 cites W2077133929 @default.
- W2400382093 cites W2083392874 @default.
- W2400382093 cites W2104195963 @default.
- W2400382093 cites W2114408988 @default.
- W2400382093 cites W2116307073 @default.
- W2400382093 cites W2120027682 @default.
- W2400382093 cites W2122292170 @default.
- W2400382093 cites W2145144950 @default.
- W2400382093 cites W2157350742 @default.
- W2400382093 cites W2166710590 @default.
- W2400382093 cites W2168765325 @default.
- W2400382093 cites W2171480577 @default.
- W2400382093 doi "https://doi.org/10.1038/mi.2015.142" @default.
- W2400382093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26838050" @default.
- W2400382093 hasPublicationYear "2016" @default.
- W2400382093 type Work @default.
- W2400382093 sameAs 2400382093 @default.
- W2400382093 citedByCount "35" @default.
- W2400382093 countsByYear W24003820932016 @default.
- W2400382093 countsByYear W24003820932017 @default.
- W2400382093 countsByYear W24003820932018 @default.
- W2400382093 countsByYear W24003820932019 @default.
- W2400382093 countsByYear W24003820932020 @default.
- W2400382093 countsByYear W24003820932021 @default.
- W2400382093 countsByYear W24003820932022 @default.
- W2400382093 countsByYear W24003820932023 @default.
- W2400382093 crossrefType "journal-article" @default.
- W2400382093 hasAuthorship W2400382093A5014454408 @default.
- W2400382093 hasAuthorship W2400382093A5017422077 @default.
- W2400382093 hasAuthorship W2400382093A5029285963 @default.
- W2400382093 hasAuthorship W2400382093A5038842968 @default.
- W2400382093 hasAuthorship W2400382093A5043264626 @default.
- W2400382093 hasAuthorship W2400382093A5048844719 @default.
- W2400382093 hasAuthorship W2400382093A5051447149 @default.
- W2400382093 hasAuthorship W2400382093A5051587677 @default.
- W2400382093 hasAuthorship W2400382093A5082033303 @default.
- W2400382093 hasAuthorship W2400382093A5089118944 @default.
- W2400382093 hasAuthorship W2400382093A5091827649 @default.
- W2400382093 hasBestOaLocation W24003820931 @default.
- W2400382093 hasConcept C126322002 @default.
- W2400382093 hasConcept C177779419 @default.
- W2400382093 hasConcept C187831198 @default.
- W2400382093 hasConcept C203014093 @default.
- W2400382093 hasConcept C2776914184 @default.
- W2400382093 hasConcept C2777209026 @default.
- W2400382093 hasConcept C2780512811 @default.
- W2400382093 hasConcept C2781065037 @default.
- W2400382093 hasConcept C2781077229 @default.
- W2400382093 hasConcept C3019368612 @default.
- W2400382093 hasConcept C502942594 @default.
- W2400382093 hasConcept C523546767 @default.
- W2400382093 hasConcept C529295009 @default.
- W2400382093 hasConcept C54355233 @default.
- W2400382093 hasConcept C55493867 @default.
- W2400382093 hasConcept C71924100 @default.