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• W2400422017 abstract "Self-perpetuating protein conformers (prions) have been described in animals (including human) and fungi (including yeast), and linked to both diseases and heritable traits (1⇓⇓–4). One would wonder if plants have them too. Indeed, a paper by Chakrabortee et al. (5), from the laboratory of Susan Lindquist, provides a first example of a plant protein behaving as a prion, at least in the heterologous (yeast) system. Chakrabortee et al. checked several domains of Arabidopsis thaliana proteins with potential prion properties, predicted by a computational search, and confirm that one of them, from the protein named Luminidependens (LD), can acquire and propagate a prion state in yeast cells when substituted for the prion domain of yeast prion protein Sup35.Notably, the LD protein is involved in the “vernalization” phenomenon, an example of epigenetic “memory” of previous environmental changes (6). The term “vernalization,” known for about a century (7), refers to triggering the flowering and reproduction process after the exposure to cold weather. Ironically, Soviet agronomist Trofim Lysenko and his followers referred to vernalization in their fight against Mendelian genetics, arguing that this phenomenon confirms heritability of acquired traits (8). Lysenko had started his scientific career by applying the vernalization procedure to increase productivity of Soviet crops (9). Following initial success, Lysenko and his colleagues rejected the chromosome theory of inheritance and postulated that a variety of cellular components may serve as carriers of heritable patterns. This attack, transformed from scientific discussion to the administrative (and sometimes criminal) persecution of opponents, eventually led to complete destruction of research and teaching in Mendelian genetics in the Union of Soviet Socialist Republics (USSR) by the end of 1940s (8). No wonder that after restoration of Mendelian genetics in the USSR in the 1960s, Lysenko’s name had become synonymous with scientific illiteracy … [↵][1]1Email: yury.chernoff{at}biology.gatech.edu. [1]: #xref-corresp-1-1" @default.
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• W2400422017 date "2016-05-23" @default.
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• W2400422017 title "Are there prions in plants?" @default.
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• W2400422017 doi "https://doi.org/10.1073/pnas.1605671113" @default.
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